Key Laboratory for Advanced Materials and Institute of Fine Chemicals, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.
Org Biomol Chem. 2018 Oct 10;16(39):7214-7222. doi: 10.1039/c8ob01970c.
An organocatalytic enantioselective Tamura cycloaddition between homophthalic anhydrides and 2-arylidene-1,3-indanediones has been developed. With 2 mol% of commercially available (DHQD)2PYR, a wide range of enantioenriched spiro-1,3-indanedione derivatives were obtained in good-to-excellent yields (68-98%), excellent diastereoselectivities (99 : 1 dr) and moderate-to-excellent enantioselectivities (up to 95% ee).
一种有机催化的对映选择性 Tamura 环加成反应，在均苯二甲酸酐和 2-亚芳基-1,3-茚二酮之间进行。使用 2 mol% 的商业可得的(DHQD)2PYR，可以以良好至优秀的收率（68-98%）、出色的非对映选择性（99:1 dr）和中等至优秀的对映选择性（高达 95%ee）获得广泛的手性富集的螺-1,3-茚二酮衍生物。
