Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, P. R. China.
Org Biomol Chem. 2018 Oct 10;16(39):7203-7213. doi: 10.1039/c8ob01634h.
A four-component reaction for electrophilic chloro(ω-alkoxy)lation of alkenes has been described. The stable chloro-iodine(iii) reagent and SOCl2 were used as electrophilic and nucleophilic chlorine sources, respectively. This approach provides a straightforward way to synthesize various useful β-chloro ω-chloroalkyl ethers from a wide range of alkenes, including electron-deficient, aromatic and unactivated alkenes. The synthetic applications of this approach were also explored in some useful transformations.
一种四组分反应用于烯烃的亲电氯（ω-烷氧基）化。稳定的氯碘（III）试剂和 SOCl2 分别用作亲电和亲核氯源。该方法提供了一种从各种烯烃（包括缺电子、芳族和非活化烯烃）合成各种有用的β-氯ω-氯代烷基醚的简便方法。该方法的合成应用也在一些有用的转化中进行了探索。
