Jouanjus Emilie, Falcou Alice, Deheul Sylvie, Roussin Anne, Lapeyre-Mestre Maryse
Equipe de Pharmacoépidémiologie, UMR 1027 Inserm-Université Paul Sabatier Toulouse III, Toulouse, France.
Centre d'Addictovigilance, Service de Pharmacologie Médicale et Clinique, CHU Toulouse, Toulouse, France.
Pharmacoepidemiol Drug Saf. 2018 Nov;27(11):1286-1292. doi: 10.1002/pds.4624. Epub 2018 Sep 25.
The increasing trend of diversion of nonprescription drugs (NPDs) by adolescents or young adults is worrying. We implemented this pilot study before a national investigation to identify requests for suspected recreational use of psychoactive drugs made by young subjects to community pharmacies.
Thirty-eight French community pharmacies were asked to complete questionnaire (with age, gender of subjects; name, form, quantity of drugs) for each suspect request formulated by subjects under 26. Besides, pharmacists were asked about the regulatory measures they thought useful to decrease this diverted use by young people. Nineteen pharmacies participated. The study covered from December 12, 2016 to January 23, 2017.
Forty-one requests mentioning 51 drugs were reported. They concerned males (85%) aged 20 years old on average, including 6 minors. The most frequent age class was that comprised between 18 and 20 years old. Codeine-containing drugs (29 reports) and promethazine (17 reports), the main components of the popular cocktail "Purple drank," were the most requested, followed by dextromethorphan (3 reports). Fifteen drugs were requested in syrup form. One request concerned the prescription drug ketamine. Pharmacists suggested to schedule the concerned NPDs to prescription-only drugs and to increase the education of students as well as the public.
Codeine and promethazine, the main components of the popular cocktail Purple drank, were the most requested. Suspect requests of psychoactive drugs made by adolescents or young adults in community pharmacies should be carefully surveyed and combined to the monitoring of falsified prescriptions.
青少年或年轻人非处方药（NPDs）滥用呈上升趋势，令人担忧。在全国性调查之前，我们开展了这项试点研究，以确定年轻受试者向社区药房提出的疑似用于消遣性使用精神活性药物的请求。
要求38家法国社区药房针对26岁以下受试者提出的每项疑似请求填写问卷（包括受试者的年龄、性别；药品名称、剂型、数量）。此外，还询问了药剂师他们认为有助于减少年轻人滥用药物的监管措施。19家药房参与了研究。研究涵盖2016年12月12日至2017年1月23日。
共报告了41项涉及51种药物的请求。涉及的主要是平均年龄20岁的男性（85%），其中包括6名未成年人。最常见的年龄组是18至20岁。含可待因的药物（29份报告）和异丙嗪（17份报告）是最常被请求的，它们是流行的“紫色饮料”鸡尾酒的主要成分，其次是右美沙芬（3份报告）。有15种药物是以糖浆形式被请求的。有一项请求涉及处方药氯胺酮。药剂师建议将相关非处方药列为仅凭处方使用的药物，并加强对学生和公众的教育。
流行的“紫色饮料”鸡尾酒的主要成分可待因和异丙嗪是最常被请求的。对于青少年或年轻人在社区药房提出的疑似精神活性药物请求应进行仔细调查，并与伪造处方的监测相结合。
