Faculty of Pharmacy, Saint-Joseph University, Beirut, Lebanon.
Laboratoire de Pharmacologie, Pharmacie Clinique et Contrôle de Qualité des Médicaments, Saint-Joseph University, Beirut, Lebanon.
Future Microbiol. 2018 Sep;13:1419-1430. doi: 10.2217/fmb-2018-0109. Epub 2018 Sep 26.
Describe susceptibility and molecular profiles among Enterobacteriaceae pathogens and to explore if war, among other factors, can affect antimicrobial resistance.
Clinical isolates from the Study for Monitoring Antimicrobial Resistance Trends associated with urinary tract and intra-abdominal infections between 2011 and 2015 were identified in Lebanon and Jordan. Susceptibility testing and molecular characterization were performed as per standard methods.
A total of 1486 Enterobacteriaceae pathogens (including unusual pathogens) were identified. Incidence rates of extended spectrum β-lactamases were high with an overall higher prevalence of resistance in Jordan compared with Lebanon. CTX-M-15 was the most prevalent extended spectrum β-lactamases produced and OXA-48 the most reported carbapenemases subtype.
Changes in healthcare system due to war could impact regional resistance patterns and which requires a continuous surveillance program and containment plan.
描述肠杆菌科病原体的易感性和分子特征，并探讨战争等因素是否会影响抗菌药物耐药性。
在黎巴嫩和约旦，对 2011 年至 2015 年间监测与尿路感染和腹腔内感染相关的抗菌药物耐药趋势的研究中的临床分离株进行了鉴定。按照标准方法进行药敏试验和分子特征分析。
共鉴定出 1486 株肠杆菌科病原体（包括罕见病原体）。超广谱β-内酰胺酶的发生率较高，与黎巴嫩相比，约旦的整体耐药率更高。CTX-M-15 是最常见的产生的超广谱β-内酰胺酶，OXA-48 是报告最多的碳青霉烯酶亚型。
由于战争导致的医疗保健系统的变化可能会影响区域耐药模式，这需要一个持续的监测计划和遏制计划。
