Fetene Dagnachew Muluye, Betts Kim S, Alati Rosa
Institute for Social Science Research, University of Queensland, Brisbane, Australia.
J Nerv Ment Dis. 2018 Nov;206(11):859-864. doi: 10.1097/NMD.0000000000000891.
Thyroid hormone plays a pivotal role in the developing brain and may affect the development of attention deficit hyperactivity disorder (ADHD). This study aimed to examine the role of maternal thyroid function during pregnancy on offspring ADHD. A total of 2912 mother-child pairs were included from the Avon Longitudinal Study of Parents and Children. Thyroid parameters were assessed during the first trimester of pregnancy. Offspring ADHD was assessed using the Development and Well-Being Assessment at the ages of 7.5 and 15 years. The odds of presenting with ADHD were estimated using generalized estimating equations. Levels of thyroid-stimulating hormone (odds ratio [OR], 0.92; 95% confidence interval [CI], 0.48-1.75), free thyroxine (OR, 1.07; 95% CI, 0.87-1.32), and thyroid peroxidase antibodies (OR, 1.00; 95% CI, 0.80-1.25) were not associated with ADHD in children aged 7.5 and 15 years. This study showed no association between maternal thyroid function and offspring ADHD.
甲状腺激素在大脑发育中起关键作用，可能影响注意力缺陷多动障碍（ADHD）的发展。本研究旨在探讨孕期母亲甲状腺功能对后代ADHD的作用。来自雅芳亲子纵向研究的2912对母婴被纳入研究。在妊娠早期评估甲状腺参数。在7.5岁和15岁时使用发育与幸福评估来评估后代的ADHD。使用广义估计方程估计患ADHD的几率。促甲状腺激素水平（优势比[OR]，0.92；95%置信区间[CI]，0.48 - 1.75）、游离甲状腺素（OR，1.07；95%CI，0.87 - 1.32）和甲状腺过氧化物酶抗体（OR，1.00；95%CI，0.80 - 1.25）与7.5岁和15岁儿童的ADHD无关。本研究表明母亲甲状腺功能与后代ADHD之间无关联。
