Langston Rebekah G, Virmani Tuhin
College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
Front Neurol. 2018 Sep 12;9:765. doi: 10.3389/fneur.2018.00765. eCollection 2018.
To objectively measure color vision dysfunction in idiopathic Parkinson's disease (iPD) using an easily administered, essentially free, modified Stroop test. Sixty-one iPD patients and 26 age-matched controls (HC) were enrolled after IRB approval and performed congruent (CST) and incongruent (IST) modified Stroop tests consisting of 40 words in 10 colors arranged in a 5 x 8 grid. The scorer was blinded to participant diagnosis. Errors on IST were defined as type 1 (written word reported rather than color) or type 2 (color reported different from the written word or its color). The iPD group and the control group completed testing with similar CST performance. On the IST, 75.4% of iPD patients had type 2 errors ( = 0.001, OR 4.907, 95%CI 1.838-13.097) compared to 38.5% HC, with a positive predictive value of 82%. The mean number of type 2 errors was also higher in the iPD group, even with MoCA scores as a covariate in the analysis. Type 1 errors were not significantly different between the groups. A univariate logistic regression model with age, gender, MoCA, normalized IST completion time and the presence/absence of type 2 errors also resulted in type 2 errors as the only significant factor in the equation ( = 0.026). The modified Stroop test incorporated into the clinical evaluation of a patient may provide a quick and inexpensive objective measure of a non-motor feature of iPD, which could help in the clinical diagnosis of iPD in conjunction with the motor assessments currently used by neurologists.
使用一种易于实施、基本免费的改良斯特鲁普测试来客观测量特发性帕金森病（iPD）患者的色觉功能障碍。在获得机构审查委员会（IRB）批准后，招募了61名iPD患者和26名年龄匹配的对照者（HC），他们进行了由10种颜色的40个单词组成的5×8网格排列的一致（CST）和不一致（IST）改良斯特鲁普测试。评分者对参与者的诊断不知情。IST上的错误被定义为1型（报告的是书写的单词而不是颜色）或2型（报告的颜色与书写的单词或其颜色不同）。iPD组和对照组在CST表现相似的情况下完成了测试。在IST上，75.4%的iPD患者有2型错误（P = 0.001，比值比4.907，95%置信区间1.838 - 13.097），而HC组为38.5%，阳性预测值为82%。即使在分析中以蒙特利尔认知评估量表（MoCA）分数作为协变量，iPD组的2型错误平均数量也更高。两组之间1型错误没有显著差异。一个包含年龄、性别、MoCA、标准化IST完成时间以及2型错误存在与否的单因素逻辑回归模型也得出2型错误是方程中唯一的显著因素（P = 0.026）。纳入患者临床评估的改良斯特鲁普测试可能为iPD的非运动特征提供一种快速且廉价的客观测量方法，这有助于结合神经科医生目前使用的运动评估进行iPD的临床诊断。
