Stevens Shanlee M, McClelland Collin M, Trusheim John E, Lee Michael S
Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, USA.
Department of Neuro-Oncology, Abbott Northwestern Hospital, Minneapolis, Minnesota, USA.
Neuroophthalmology. 2018 Jan 26;42(5):302-305. doi: 10.1080/01658107.2017.1419367. eCollection 2018 Oct.
Carboplatin is a platinum-based chemotherapeutic agent used for the treatment of many solid tumors. Peripheral neuropathy is a common side effect; but, to our knowledge, ocular motor cranial neuropathies have not been reported in the literature. We describe a case of persistent third and fourth nerve palsies after systemic administration of intra-arterial carboplatin for glioblastoma multiforme. Neither nerve regained function after carboplatin was stopped.
卡铂是一种用于治疗多种实体瘤的铂类化疗药物。周围神经病变是一种常见的副作用;但据我们所知,眼动性颅神经病变在文献中尚未见报道。我们描述了一例在经动脉注射卡铂治疗多形性胶质母细胞瘤后出现持续性动眼神经和滑车神经麻痹的病例。停用卡铂后,这两条神经均未恢复功能。