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[富含血小板血浆和生长因子在肌肉骨骼系统中的临床应用]

[Clinical administration of platelet-rich plasma and growth factors to the musculoskeletal system].

作者信息

Leitner L, Gruber G, Lohberger B, Kaltenegger H, Leithner A, Sadoghi P

机构信息

Univ.-Klinik für Orthopädie und Traumatologie, Medizinische Universität Graz, Auenbruggerplatz 5, 8036, Graz, Österreich.

出版信息

Orthopade. 2019 Jan;48(1):105-116. doi: 10.1007/s00132-018-3643-3.

DOI:10.1007/s00132-018-3643-3
PMID:30259059
Abstract

Platelet-rich plasma (PRP) and growth factors have been increasing in popularity for the orthopedic treatment of degenerative and traumatic diseases. The treatment concept is based on the substitution of growth-inducing substances in tissues with low or absent regeneration capacity (cartilage, tendons) as well as for the induction or further acceleration of growth and regeneration (bone, muscle). This review article provides an overview on the clinical feasibility of usage and a summary of the current study situation.

摘要

富含血小板血浆(PRP)和生长因子在退行性和创伤性疾病的骨科治疗中越来越受欢迎。该治疗理念基于用生长诱导物质替代再生能力低或无再生能力的组织(软骨、肌腱),以及诱导或进一步加速生长和再生(骨骼、肌肉)。本文综述提供了关于其临床应用可行性的概述以及当前研究情况的总结。

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Orthopade. 2019 Jan;48(1):105-116. doi: 10.1007/s00132-018-3643-3.
2
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本文引用的文献

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Bone grafts and biomaterials substitutes for bone defect repair: A review.用于骨缺损修复的骨移植材料和生物材料替代品:综述
Bioact Mater. 2017 Jun 7;2(4):224-247. doi: 10.1016/j.bioactmat.2017.05.007. eCollection 2017 Dec.
2
Anti-Angiogenics: Their Value in Lung Cancer Therapy.抗血管生成药物:在肺癌治疗中的价值。
Oncol Res Treat. 2018;41(4):172-180. doi: 10.1159/000488119. Epub 2018 Mar 23.
3
[Bone substitute materials as local drug carriers : Current status of substitutes of various origins].[作为局部药物载体的骨替代材料:各种来源替代物的现状]
Orthopade. 2018 Jan;47(1):10-23. doi: 10.1007/s00132-017-3505-4.
4
Platelet-Rich Plasma Derived Growth Factors Contribute to Stem Cell Differentiation in Musculoskeletal Regeneration.富含血小板血浆衍生生长因子有助于肌肉骨骼再生中的干细胞分化。
Front Chem. 2017 Oct 31;5:89. doi: 10.3389/fchem.2017.00089. eCollection 2017.
5
An evidence-based evaluation on the use of platelet rich plasma in orthopedics - a review of the literature.富血小板血浆在骨科应用的循证评估——文献综述
SICOT J. 2017;3:57. doi: 10.1051/sicotj/2017036. Epub 2017 Oct 9.
6
The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials.富血小板血浆治疗膝骨关节炎时对疼痛和身体功能的时间效应:随机对照试验的系统评价和荟萃分析
J Orthop Surg Res. 2017 Jan 23;12(1):16. doi: 10.1186/s13018-017-0521-3.
7
Efficacy of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Meta-analysis of Randomized Controlled Trials.富血小板血浆治疗膝骨关节炎的疗效:一项随机对照试验的荟萃分析
Arthroscopy. 2017 Mar;33(3):659-670.e1. doi: 10.1016/j.arthro.2016.09.024. Epub 2016 Dec 22.
8
Platelet-rich plasma for the treatment of bone defects: from pre-clinical rational to evidence in the clinical practice. A systematic review.富血小板血浆治疗骨缺损:从临床前理论依据到临床实践证据。一项系统综述。
Int Orthop. 2017 Feb;41(2):221-237. doi: 10.1007/s00264-016-3342-9. Epub 2016 Nov 26.
9
The roles of vascular endothelial growth factor in bone repair and regeneration.血管内皮生长因子在骨修复与再生中的作用。
Bone. 2016 Oct;91:30-8. doi: 10.1016/j.bone.2016.06.013. Epub 2016 Jun 25.
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Does the Use of Platelet-Rich Plasma at the Time of Surgery Improve Clinical Outcomes in Arthroscopic Rotator Cuff Repair When Compared With Control Cohorts? A Systematic Review of Meta-analyses.与对照组相比,手术时使用富血小板血浆是否能改善关节镜下肩袖修复的临床效果?一项Meta分析的系统评价。
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