Section of Specialized Endocrinology, Department of Endocrinology, Oslo University Hospital Rikshospitalet, P.b. 4950 Nydalen, 0424, Oslo, Norway.
Faculty of Medicine, University of Oslo, Oslo, Norway.
Endocrine. 2019 Jan;63(1):171-176. doi: 10.1007/s12020-018-1752-8. Epub 2018 Sep 26.
Precise radiological assessment of tumour volume is important in the follow-up of non-functioning pituitary adenomas (NFPAs). We compared the reliability of two methods for tumour volume measurements in the pre- and postoperative setting.
We assessed the volume of 22 NFPAs at magnetic resonance imaging (MRI) scans before surgery and the first and third postoperative MRI obtained after submission from hospital. Volumetric assessments were performed both by summation of slices (SOS) and by diameter measures. All volumes were calculated independently by two readers.
The preoperative intra- and inter-rater reliability was good for both the SOS and the diameter method (intraclass correlation coefficient (ICC) 0.996 and 0.990, and ICC: 0.982 and 0.967, respectively). The first postoperative investigation showed poorer intra- and inter-rater reliability for both methods (ICC: 0.872 and 0.791 and ICC: 0.792 and 0.810, respectively). The third postoperative MRI showed good intra-rater reliability (ICC: 0.961 and 0.962, respectively), but poorer inter-rater reliability for both methods (ICC: 0.759 and 0.703, respectively). Volume assessment by SOS presented overall slightly higher reliability than the diametric method. Overall, the reliability between the two methods was good when measured by the same reader (ICC: 0.988, 0.945 and 0.962, for the preoperative, first and third postoperative MRI, respectively).
The preoperative intra- and inter-rater reliabilities were satisfactory for both the SOS and diametric method. Postoperative MRI scans showed poorer reliability, suggesting that measurements at these time points should be interpreted with care. For each MRI scan, reliability between methods was satisfactory when investigated by the same reader.
在非功能性垂体腺瘤（NFPAs）的随访中，精确的肿瘤体积放射学评估很重要。我们比较了两种方法在术前和术后测量肿瘤体积的可靠性。
我们评估了 22 例 NFPAs 在术前磁共振成像（MRI）扫描和术后第一次和第三次 MRI 扫描中的体积。体积评估分别通过切片总和（SOS）和直径测量进行。所有体积均由两位读者独立计算。
术前 SOS 和直径法的组内和组间可靠性均良好（组内相关系数（ICC）分别为 0.996 和 0.990，ICC 分别为 0.982 和 0.967）。第一次术后检查显示两种方法的组内和组间可靠性均较差（ICC 分别为 0.792 和 0.810，ICC 分别为 0.792 和 0.810）。第三次术后 MRI 显示出良好的组内可靠性（ICC 分别为 0.961 和 0.962），但两种方法的组间可靠性均较差（ICC 分别为 0.759 和 0.703）。SOS 法评估的体积总体上略高于直径法的可靠性。总的来说，当由同一读者测量时，两种方法之间的可靠性良好（术前、第一次和第三次 MRI 的 ICC 分别为 0.988、0.945 和 0.962）。
术前 SOS 和直径法的组内和组间可靠性均令人满意。术后 MRI 扫描显示可靠性较差，提示在这些时间点测量时应谨慎解释。对于每次 MRI 扫描，当由同一读者进行调查时，两种方法之间的可靠性均令人满意。
