Krysiak Robert, Drosdzol-Cop Agnieszka, Skrzypulec-Plinta Violetta, Okopień Bogusław
Chair of Woman's Health, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
Endokrynol Pol. 2018;69(6):688-694. doi: 10.5603/EP.a2018.0062. Epub 2018 Sep 27.
Statins were found to improve erectile function in men. No previous study has prospectively investigated sexual functioning in women receiving these agents. The aim of this study was to evaluate the impact of atorvastatin therapy on female sexual function, and depressive symptoms in young women with elevated cholesterol levels.
The study included 14 women with elevated cholesterol levels and 14 matched women with normal plasma lipids. Hypercholesterolaemic women were then treated with atorvastatin (20-40 mg daily) for 24 weeks. Apart from measuring plasma lipids, at the beginning and at the end of the study, all participants of the study completed questionnaires evaluating sexual function (Female Sexual Function Index - FSFI) and the presence and severity of depressive symptoms (Beck Depression Inventory-Second Edition - BDI-II).
The mean total FSFI score was insignificantly lower, while the BDI-II score was higher in women with hypercholesterolaemia than in the control group. Both groups significantly differed in domain scores for arousal and orgasm. Atorvastatin decreased the domain score for desire, increased the domain score for orgasm, but did not affect the total FSFI score and the remaining domain scores. Moreover, atorvastatin tended to reduce the BDI-II score. Treatment-induced changes in desire, orgasm, and the BDI-II did not correlate with the effect of atorvastatin on plasma lipids.
Atorvastatin treatment produces a relatively mild effect on sexual functioning and mood in women, affecting only selected elements of female sexual behaviour.
他汀类药物被发现可改善男性勃起功能。此前尚无研究对接受这些药物治疗的女性性功能进行前瞻性调查。本研究的目的是评估阿托伐他汀治疗对胆固醇水平升高的年轻女性性功能及抑郁症状的影响。
本研究纳入了14名胆固醇水平升高的女性和14名血脂正常的匹配女性。高胆固醇血症女性随后接受阿托伐他汀（每日20 - 40毫克）治疗24周。除了测量血脂外，在研究开始和结束时，所有研究参与者均完成了评估性功能（女性性功能指数 - FSFI）以及抑郁症状的存在情况和严重程度（贝克抑郁量表第二版 - BDI-II）的问卷调查。
高胆固醇血症女性的平均FSFI总分略低，而BDI-II得分高于对照组。两组在性唤起和性高潮领域得分上有显著差异。阿托伐他汀降低了性欲领域得分，提高了性高潮领域得分，但未影响FSFI总分及其他领域得分。此外，阿托伐他汀有降低BDI-II得分的趋势。治疗引起的性欲、性高潮及BDI-II的变化与阿托伐他汀对血脂的影响无关。
阿托伐他汀治疗对女性性功能和情绪产生相对轻微的影响，仅影响女性性行为的特定方面。
