Shumaker Abby C, Bullard Heather M, Churpek Jane, Knoebel Randall W
1 Department of Pharmacy, Blessing Hospital, Quincy, IL, USA.
2 Department of Pharmacy, The University of Chicago Medicine, Chicago, IL, USA.
J Oncol Pharm Pract. 2019 Oct;25(7):1758-1761. doi: 10.1177/1078155218801055. Epub 2018 Sep 27.
Drug-drug interactions between digoxin and the triazole antifungal agents, mediated via various cytochrome P450 isozymes, have been described in the literature. Posaconazole is not extensively metabolized by these isozymes but is both a p-glycoprotein (P-gp) substrate and inhibitor. To our knowledge, there have been no published cases of clinically significant posaconazole-digoxin drug-drug interactions. We report an interaction between posaconazole (300 mg by mouth daily) and digoxin (0.25 mg by mouth daily, Monday through Friday) resulting in atrial fibrillation with slow ventricular response and degenerating into polymorphic ventricular tachycardia.
文献中已描述了地高辛与三唑类抗真菌药之间通过各种细胞色素P450同工酶介导的药物相互作用。泊沙康唑不会被这些同工酶广泛代谢，但它既是P-糖蛋白（P-gp）的底物，也是其抑制剂。据我们所知，尚未有关于具有临床意义的泊沙康唑-地高辛药物相互作用的病例报道。我们报告了一例泊沙康唑（每日口服300毫克）与地高辛（周一至周五每日口服0.25毫克）之间的相互作用，该相互作用导致心房颤动伴心室反应缓慢，并恶化为多形性室性心动过速。
