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法洛四联症患儿经跨环补片修复术时单叶瓣膜置入:功能性肺动脉瓣并不能改善术后即刻结局。

Monocusp valve placement in children with tetralogy of Fallot undergoing repair with transannular patch: A functioning pulmonary valve does not improve immediate postsurgical outcomes.

作者信息

Singh Nikki M, Loomba Rohit S, Gudausky Todd M, Mitchell Michael E

机构信息

Division of Pediatric Cardiology, Medical College of Wisconsin, Herma Heart Institute at Children's Hospital of Wisconsin, Milwaukee, Wisconsin.

Advocate Children's Heart Institute, Advocate Children's Hospital, Oak Lawn, Illinois.

出版信息

Congenit Heart Dis. 2018 Nov;13(6):935-943. doi: 10.1111/chd.12670. Epub 2018 Sep 27.

Abstract

INTRODUCTION

In patients with tetralogy of Fallot (TOF), use of transannular patch (TAP) may be required in order to relieve significant right ventricular outflow tract obstruction, subsequently resulting in pulmonary insufficiency (PI). The monocusp valve has been used to temporarily reduce insufficiency in hopes to improve short and midterm outcomes. The purpose of this study was to assess for potential benefits of the monocusp valve in this subset of patients.

DESIGN

Between 2005 and 2016, 119 patients with TOF with pulmonary stenosis who underwent repair with TAP were analyzed, 43 (36.1%) had a monocusp valve placed. Immediate outcomes were assessed by postoperative echocardiograms, ICU data including time to extubation, chest tube duration, reintervention, length of stay, and mortality.

RESULTS

Median age of repair was similar for monocusp group at 143.5 days and nonmonocusp at 137.0 days (P = .93). Peak preoperative right ventricular outflow tract obstruction was higher in the monocusp group (80 mm Hg vs. 70 mm Hg, P ≤ .01). Patients who had monocusp placed had longer bypass time. There was less PI for monocusp group immediately after repair and at discharge (P ≤ .01). There was no difference in days of intubation, chest tube duration, length of hospitalization, reintervention rates, or mortality.

CONCLUSION

Decreasing the degree of PI with a monocusp valve in patients undergoing repair for TOF repair with TAP does not improve clinical outcomes in the immediate postoperative period.

摘要

引言

对于法洛四联症(TOF)患者,可能需要使用跨环补片(TAP)来缓解严重的右心室流出道梗阻,进而导致肺动脉瓣关闭不全(PI)。单叶瓣膜已被用于暂时减轻关闭不全,以期改善短期和中期预后。本研究的目的是评估单叶瓣膜在这部分患者中的潜在益处。

设计

对2005年至2016年间119例行TAP修复术的TOF合并肺动脉狭窄患者进行分析,其中43例(36.1%)植入了单叶瓣膜。通过术后超声心动图、重症监护病房(ICU)数据评估即时预后,包括拔管时间、胸管留置时间、再次干预、住院时间和死亡率。

结果

单叶瓣膜组修复时的中位年龄为143.5天,非单叶瓣膜组为137.0天,两者相似(P = 0.93)。单叶瓣膜组术前右心室流出道梗阻峰值更高(80 mmHg对70 mmHg,P≤0.01)。植入单叶瓣膜的患者体外循环时间更长。修复后即刻及出院时,单叶瓣膜组的PI较轻(P≤0.01)。插管天数、胸管留置时间、住院时间、再次干预率或死亡率无差异。

结论

对于行TAP修复术的TOF患者,使用单叶瓣膜降低PI程度并不能改善术后即刻的临床预后。

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