Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Chronic Disease Research Institute, School of Public Health, Zhejiang University, Hangzhou, Zhejiang, China.
Obesity (Silver Spring). 2018 Oct;26(10):1637-1643. doi: 10.1002/oby.22294. Epub 2018 Sep 27.
This study was undertaken to investigate the associations of platelet indices with body fat, including body fat mass and fat distribution.
A total of 3,327 individuals aged 18 to 80 were enrolled. Body fat was assessed by dual-energy x-ray absorptiometry. Blood samples were collected to measure platelet indices (platelet count [PLT], plateletcrit [PCT], mean platelet volume, platelet distribution width, and platelet large cell ratio). Adjusted multivariate linear regression models were used to identify the associations of platelet indices with body fat.
PLT was positively associated with BMI, waist circumference, waist-hip ratio, total fat mass percentage, trunk fat mass percentage, android fat mass percentage, and android to gynoid fat ratio but negatively associated with gynoid fat mass percentage, total lean mass percentage, and skeletal muscle mass index. Similar associations were found between PCT and body fat. However, no significant associations were found between the other three platelet indices and body fat.
Both PLT and PCT were associated with body fat, and the associations depended on fat location. Because PCT is mainly influenced by PLT, these associations suggest that platelet quantity is more closely related to body fat mass and fat distribution.
本研究旨在探讨血小板指数与体脂的相关性，包括体脂总量和脂肪分布。
共纳入 3327 名 18 至 80 岁的个体。采用双能 X 射线吸收法评估体脂。采集血样以测量血小板指数（血小板计数[PLT]、血小板压积[PCT]、平均血小板体积、血小板分布宽度和大血小板比率）。采用调整后的多元线性回归模型来确定血小板指数与体脂的相关性。
PLT 与 BMI、腰围、腰臀比、总脂肪量百分比、躯干脂肪量百分比、腹型脂肪量百分比和腹型与臀型脂肪比呈正相关，与臀型脂肪量百分比、总瘦体重百分比和骨骼肌质量指数呈负相关。PCT 与体脂也存在类似的相关性。然而，其他三个血小板指数与体脂之间没有显著相关性。
PLT 和 PCT 均与体脂相关，且这种相关性取决于脂肪的位置。由于 PCT 主要受 PLT 影响，这些相关性表明血小板数量与体脂总量和脂肪分布更为密切相关。
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