Kalyoncu Derya
Istinye State Hospital, Istinye Street No. 98, Sariyer, Istanbul, Turkey.
Eur J Pediatr. 2023 Sep;182(9):3989-3995. doi: 10.1007/s00431-023-05082-1. Epub 2023 Jun 29.
The aim of the study was to determine the association between platelet indices and obesity in children. A total of 190 overweight or obese children (mean age: 13.29 ± 2.54, M/F: 0.74) and 100 normal-weight children (mean age: 12.72 ± 2.23, M/F:1.04) were enrolled in the study. Platelet count (PLT), platelet indices, and ratios were determined. No significant difference was observed in terms of mean platelet volume (MPV) and platelet distribution width (PDW) levels and MPV/plateletcrit (PCT) and PDW/PCT ratios between overweight, obese, and normal-weight groups, whereas significant differences were observed in terms of PLT, PCT, MPV/PLT, and PDW/PLT ratios between each group. PLT and PCT levels were significantly higher in the obese group than in the overweight and normal-weight groups (P = 0.003, P = 0.002, respectively). Children with obesity had lower MPV/PLT and PDW/PLT ratios than the other groups (P = 0.001, P = 0.02, respectively). Overweight and obese children with insulin resistance (IR) had higher PLT and lower MPV/PLT, and PDW/PLT ratios than the children without IR (P = 0.034, P = 0.04, P = 0.013, respectively).
Significant differences were observed in terms of PLT, PCT, MPV/PLT, and PDW/PLT between overweight, obese, and normal-weight children.
• Obesity is associated with a chronic low-grade systemic inflammation. • Platelets play a crucial role in coagulation, hemostasis, thrombosis, immunomodulatory processes, inflammation, and atherothrombosis.
• Significant differences were observed in terms of PLT, PCT, MPV/PLT, and PDW/PLT between overweight, obese, and normal-weight children. • Overweight and obese children with insulin resistance had higher PLT and lower MPV/PLT and PDW/PLT ratios than the children without insülin resistance.
本研究的目的是确定儿童血小板指标与肥胖之间的关联。共有190名超重或肥胖儿童（平均年龄：13.29±2.54，男/女：0.74）和100名正常体重儿童（平均年龄：12.72±2.23，男/女：1.04）纳入本研究。测定了血小板计数（PLT）、血小板指标及比值。超重、肥胖和正常体重组之间在平均血小板体积（MPV）、血小板分布宽度（PDW）水平以及MPV/血小板压积（PCT）和PDW/PCT比值方面未观察到显著差异，而各组之间在PLT、PCT、MPV/PLT和PDW/PLT比值方面观察到显著差异。肥胖组的PLT和PCT水平显著高于超重和正常体重组（分别为P = 0.003，P = 0.002）。肥胖儿童的MPV/PLT和PDW/PLT比值低于其他组（分别为P = 0.001，P = 0.02）。有胰岛素抵抗（IR）的超重和肥胖儿童的PLT较高，而MPV/PLT和PDW/PLT比值低于无IR的儿童（分别为P = 0.034，P = 0.04，P = 0.013）。
超重、肥胖和正常体重儿童在PLT、PCT、MPV/PLT和PDW/PLT方面存在显著差异。
•肥胖与慢性低度全身炎症相关。•血小板在凝血、止血、血栓形成、免疫调节过程、炎症和动脉粥样硬化血栓形成中起关键作用。
•超重、肥胖和正常体重儿童在PLT、PCT、MPV/PLT和PDW/PLT方面存在显著差异。•有胰岛素抵抗的超重和肥胖儿童的PLT较高，而MPV/PLT和PDW/PLT比值低于无胰岛素抵抗的儿童。
