乙肝疫苗与多发性硬化症发病风险：系统评价与荟萃分析。
HBV vaccine and risk of developing multiple sclerosis: a systematic review and meta-analysis.
机构信息
Department of Public Health and Infectious Diseases, Sapienza University, Rome, Italy.
Faculty of Pharmacy, University of Lisbon, Portugal.
出版信息
Hum Vaccin Immunother. 2021 Jul 3;17(7):2273-2278. doi: 10.1080/21645515.2018.1528835.
Abstract
Hepatitis B virus (HBV) infection is one the most common in the world. Aim of this study is to perform a systematic review on the relationship between HBV vaccination and multiple sclerosis. Research was conducted on Pubmed, ISI Web of Science, and Scopus. Terms " and "" were used. Meta-analysis and metaregression were performed. 414 papers were found. Seven articles were selected. For the reported crude risk estimates for MS no statistically significant association was observed with pooled OR 1,19 (95%CI: 0,96-1,49). For the adjusted ORs, the pooled odds ratio (OR) was 0, 965 (95%CI: 0,886- 1,051). Meta regression show that year of publication is negatively (β: -0,019; P < 0.001) and NOS score and publishing in Europe are positively associated with O.R. value. Funnel plot showed the presence of publication bias. Results showed that Hepatitis B vaccination is not associated with an increased risk of developing MS.
摘要
乙型肝炎病毒（HBV）感染是世界上最常见的感染之一。本研究旨在对乙型肝炎疫苗接种与多发性硬化症之间的关系进行系统评价。研究在 Pubmed、ISI Web of Science 和 Scopus 上进行。使用了“和”和“”这两个术语。进行了荟萃分析和荟萃回归。共发现 414 篇论文，选择了 7 篇文章。对于报告的多发性硬化症的未调整风险估计，合并 OR 为 1.19（95%CI：0.96-1.49），无统计学显著相关性。对于调整后的 ORs，合并优势比（OR）为 0.965（95%CI：0.886-1.051）。荟萃回归显示，发表年份呈负相关（β：-0.019；P<0.001），NOS 评分和在欧洲发表与 O.R. 值呈正相关。漏斗图显示存在发表偏倚。结果表明，乙型肝炎疫苗接种与多发性硬化症的发病风险增加无关。
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