mTOR-dependent autophagy contributes to end-organ resistance and serves as target for treatment in autoimmune disease.
作者信息
Perl Andras
机构信息
Division of Rheumatology, Departments of Medicine and Microbiology and Immunology, State University of New York, Upstate Medical University, College of Medicine, Syracuse, New York 13210, USA.
出版信息
EBioMedicine. 2018 Oct;36:12-13. doi: 10.1016/j.ebiom.2018.09.033. Epub 2018 Sep 24.
Abstract
摘要
相似文献
1
mTOR-dependent autophagy contributes to end-organ resistance and serves as target for treatment in autoimmune disease.
EBioMedicine. 2018 Oct;36:12-13. doi: 10.1016/j.ebiom.2018.09.033. Epub 2018 Sep 24.
2
The immunobiology of mTOR in autoimmunity.
J Autoimmun. 2020 Jun;110:102373. doi: 10.1016/j.jaut.2019.102373. Epub 2019 Dec 9.
3
mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and aging.
Ann N Y Acad Sci. 2015 Jun;1346(1):33-44. doi: 10.1111/nyas.12756. Epub 2015 Apr 23.
4
DINP aggravates autoimmune thyroid disease through activation of the Akt/mTOR pathway and suppression of autophagy in Wistar rats.
Environ Pollut. 2019 Feb;245:316-324. doi: 10.1016/j.envpol.2018.10.108. Epub 2018 Oct 30.
5
mTOR signaling and metabolic regulation of T cells: new potential therapeutic targets in autoimmune diseases.
Curr Pharm Des. 2011 Dec;17(35):3888-97. doi: 10.2174/138161211798357809.
6
Betaine modulates oxidative stress, inflammation, apoptosis, autophagy, and Akt/mTOR signaling in methionine-choline deficiency-induced fatty liver disease.
Eur J Pharmacol. 2019 Apr 5;848:39-48. doi: 10.1016/j.ejphar.2019.01.043. Epub 2019 Jan 25.
7
Aflatoxin B promotes autophagy associated with oxidative stress-related PI3K/AKT/mTOR signaling pathway in mice testis.
Environ Pollut. 2019 Dec;255(Pt 2):113317. doi: 10.1016/j.envpol.2019.113317. Epub 2019 Oct 3.
8
Induction of autophagy by salidroside through the AMPK-mTOR pathway protects vascular endothelial cells from oxidative stress-induced apoptosis.
Mol Cell Biochem. 2017 Jan;425(1-2):125-138. doi: 10.1007/s11010-016-2868-x. Epub 2016 Nov 15.
9
Particulate matter exposure induces the autophagy of macrophages via oxidative stress-mediated PI3K/AKT/mTOR pathway.
Chemosphere. 2017 Jan;167:444-453. doi: 10.1016/j.chemosphere.2016.10.024. Epub 2016 Oct 14.
10
Copper or/and arsenic induces autophagy by oxidative stress-related PI3K/AKT/mTOR pathways and cascaded mitochondrial fission in chicken skeletal muscle.
J Inorg Biochem. 2018 Nov;188:1-8. doi: 10.1016/j.jinorgbio.2018.08.001. Epub 2018 Aug 4.
引用本文的文献
1
Complement activity and autophagy are dysregulated in the lungs of patients with nonresolvable COVID-19 requiring lung transplantation.
Respir Res. 2025 Feb 27;26(1):68. doi: 10.1186/s12931-025-03152-6.
2
Targeting toll-like receptor 4 (TLR4) and the NLRP3 inflammasome: Novel and emerging therapeutic targets for hyperuricaemia nephropathy.
Biomol Biomed. 2023 Dec 1;24(4):688-697. doi: 10.17305/bb.2023.9838.
3
Autophagy dysregulation in trichloroethene-mediated inflammation and autoimmune response.
Toxicology. 2023 Mar 15;487:153468. doi: 10.1016/j.tox.2023.153468. Epub 2023 Feb 26.
4
Circ-EEF2 facilitated autophagy via interaction with mir-6881-3p and ANXA2 in EOC.
Am J Cancer Res. 2020 Nov 1;10(11):3737-3751. eCollection 2020.
5
Sirolimus as Rescue Therapy for Refractory/Relapsed Immune Thrombocytopenia: Results of a Single-Center, Prospective, Single-Arm Study.
Front Med (Lausanne). 2020 Mar 31;7:110. doi: 10.3389/fmed.2020.00110. eCollection 2020.
6
Roles of mTOR Signaling in Tissue Regeneration.
Cells. 2019 Sep 12;8(9):1075. doi: 10.3390/cells8091075.
7
ALKBH5 inhibited autophagy of epithelial ovarian cancer through miR-7 and BCL-2.
J Exp Clin Cancer Res. 2019 Apr 15;38(1):163. doi: 10.1186/s13046-019-1159-2.
本文引用的文献
1
Boosting mTOR-dependent autophagy via upstream TLR4-MyD88-MAPK signalling and downstream NF-κB pathway quenches intestinal inflammation and oxidative stress injury.
EBioMedicine. 2018 Sep;35:345-360. doi: 10.1016/j.ebiom.2018.08.035. Epub 2018 Aug 29.
2
Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1/2 trial.
Lancet. 2018 Mar 24;391(10126):1186-1196. doi: 10.1016/S0140-6736(18)30485-9. Epub 2018 Mar 15.
3
mTOR Signaling in Growth, Metabolism, and Disease.
Cell. 2017 Mar 9;168(6):960-976. doi: 10.1016/j.cell.2017.02.004.
4
N-Acetylcysteine improves intestinal function in lipopolysaccharides-challenged piglets through multiple signaling pathways.
Amino Acids. 2017 Dec;49(12):1915-1929. doi: 10.1007/s00726-017-2389-2. Epub 2017 Mar 7.
5
Mitochondrial Dysfunction in the Liver and Antiphospholipid Antibody Production Precede Disease Onset and Respond to Rapamycin in Lupus-Prone Mice.
Arthritis Rheumatol. 2016 Nov;68(11):2728-2739. doi: 10.1002/art.39791.
6
mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and aging.
Ann N Y Acad Sci. 2015 Jun;1346(1):33-44. doi: 10.1111/nyas.12756. Epub 2015 Apr 23.
7
Genetics of systemic lupus erythematosus: immune responses and end organ resistance to damage.
Curr Opin Immunol. 2014 Dec;31:87-96. doi: 10.1016/j.coi.2014.10.004. Epub 2014 Oct 25.
8
Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice.
Nat Commun. 2014 May 12;5:3837. doi: 10.1038/ncomms4837.
9
Mechanistic target of rapamycin activation triggers IL-4 production and necrotic death of double-negative T cells in patients with systemic lupus erythematosus.
J Immunol. 2013 Sep 1;191(5):2236-46. doi: 10.4049/jimmunol.1301005. Epub 2013 Aug 2.
10
N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: a randomized, double-blind, placebo-controlled trial.
Arthritis Rheum. 2012 Sep;64(9):2937-46. doi: 10.1002/art.34502.
Zotero 插件