Yamatsu Atsushi, Yamashita Yusuke, Pandharipande Tukaram, Maru Isafumi, Kim Mujo
Pharma Foods International Co., Ltd., Kyoto, 615-8245 Japan.
Food Sci Biotechnol. 2016 Apr 30;25(2):547-551. doi: 10.1007/s10068-016-0076-9. eCollection 2016.
The effects of γ-aminobutyric acid (GABA) on sleep and its levels in blood after oral administration were investigated in humans. A randomized, single-blind, placebo-controlled crossover-designed study was conducted to evaluate the effect of GABA on sleep. Sleep was evaluated by electroencephalography (EEG) after oral GABA administration. GABA significantly shortened sleep latency and increased the total non-rapid eye movement (non-REM) sleep time. Questionnaires showed that subjects receiving GABA realized its effects on sleep. In addition, the blood level of GABA after administration was investigated, and the absorption and metabolism rates of GABA were determined. GABA was quickly absorbed, and the blood level of GABA was the highest 30 min after oral administration, with a subsequent decrease in concentration. As GABA strongly affected the early stage of sleep, the effect of GABA on sleep may be connected to its levels in blood.
在人体中研究了γ-氨基丁酸（GABA）口服给药后对睡眠的影响及其血液中的水平。进行了一项随机、单盲、安慰剂对照的交叉设计研究，以评估GABA对睡眠的影响。口服GABA后通过脑电图（EEG）评估睡眠情况。GABA显著缩短了睡眠潜伏期并增加了总的非快速眼动（non-REM）睡眠时间。问卷调查显示，接受GABA的受试者意识到了其对睡眠的影响。此外，还研究了给药后血液中GABA的水平，并测定了GABA的吸收和代谢率。GABA吸收迅速，口服后30分钟血液中GABA水平最高，随后浓度下降。由于GABA对睡眠早期有强烈影响，GABA对睡眠的影响可能与其血液中的水平有关。
