盾叶薯蓣籽油（ZSO）对高脂血症大鼠的降脂作用及对3T3-L1脂肪细胞的脂解作用
Lipid-lowering effects of Siebold & Zucc. seed oil (ZSO) in hyperlipidemic rats and lipolytic effects in 3T3-L1 adipocytes.
作者信息
Kim Kyoung Kon, Kim Tae Woo, Kang Yun Hwan, Kim Dae Jung, Choe Myeon
机构信息
1Department of Bio-Health Technology, College of Biomedical Science, Kangwon National University, Chuncheon, Gangwon, 24341 Korea.
2Well-Being Bioproducts R&D Regional Innovation Center, Kangwon National University, Chuncheon, Gangwon, 24341 Korea.
出版信息
Food Sci Biotechnol. 2016 Oct 31;25(5):1427-1436. doi: 10.1007/s10068-016-0222-4. eCollection 2016.
On the basis of the antiatherosclerotic effect of , the therapeutic potential of seed oil (ZSO) was tested in terms of the blood lipid profile and obesity in rats. The lipolytic effects of ZSO were determined in adipocytes and the total body and liver weight were decreased in rats. Compared with the high-cholesterol high-fat (HCHF) group, the rats in the HCHF+ZSO group showed improved levels of hyperlipidemia indicators. Furthermore, western blot analysis confirmed that the improvement of hyperlipidemia indicators was induced by stimulation of lipoprotein lipase expression. Additional results indicated that the reduction in body weight was likely caused by phosphorylation of hormone-sensitive lipase (HSL) via the protein kinase A pathway, ultimately leading to lipolysis. In conclusion, the results of the experiment showed that ZSO improved the lipid profiles in the blood, lowering cardiovascular disease and arteriosclerosis and degrading cellular lipids by activating HSL.
基于[未提及物质]的抗动脉粥样硬化作用，对[未提及物质]籽油（ZSO）在大鼠血脂水平和肥胖方面的治疗潜力进行了测试。在脂肪细胞中测定了ZSO的脂解作用，并且大鼠的总体重和肝脏重量均有所下降。与高胆固醇高脂肪（HCHF）组相比，HCHF + ZSO组的大鼠血脂异常指标水平有所改善。此外，蛋白质印迹分析证实，脂蛋白脂肪酶表达的刺激诱导了血脂异常指标的改善。其他结果表明，体重减轻可能是由于激素敏感性脂肪酶（HSL）通过蛋白激酶A途径磷酸化所致，最终导致脂解。总之，[未提及物质]实验的结果表明，ZSO通过激活HSL改善了血液中的脂质状况，降低了心血管疾病和动脉硬化的风险，并降解了细胞脂质。
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