在小鼠骨髓基质D1细胞中的脂肪生成抑制作用。
Adipogenesis inhibitory effects of in mouse bone marrow stromal D1 cells.
作者信息
Kwon Myeong Sook, Karadeniz Fatih, Kim Jung-Ae, Seo Youngwan, Kong Chang-Suk
机构信息
1Department of Food and Nutrition, College of Medical and Life Sciences, Silla University, Busan, 46958 Korea.
2Marine Biotechnology Center for Pharmaceuticals and Foods, Silla University, Busan, 46958 Korea.
出版信息
Food Sci Biotechnol. 2016 Mar 31;25(Suppl 1):125-131. doi: 10.1007/s10068-016-0109-4. eCollection 2016.
Unbalanced differentiation of bone marrow cells into adipocytes rather than osteoblasts causes severe bone-related disorders, such as osteoporosis. Natural products that can act against unbalanced differentiation are targeted for development of functional dietary supplements. , a halophyte known for anti-oxidant constituents, was studied for beneficial effects in prevention of adipogenesis of bone marrow stromal D1 cells . Solvent-partitioned extract fractions of prevented differentiating D1 cells from accumulating lipids. Expression of the key adipogenic markers PPARγ, SREBP1c, and C/EBPα were inhibited at mRNA and protein levels. Suppressed protein levels of the phosphorylated MAPK-related factors ERK, JNK, and p-38 indicated inhibition of PPARγ pathway-linked adipogenesis in D1 cells. The n-BuOH fraction was the most effective fraction for bioactive substances. inhibited adipogenesis in D1 bone marrow stromal cells due to the presence of bioactive flavonoids.
骨髓细胞向脂肪细胞而非成骨细胞的不平衡分化会导致严重的骨相关疾病，如骨质疏松症。能够对抗这种不平衡分化的天然产物成为功能性膳食补充剂开发的目标。盐生植物 ，因其抗氧化成分而闻名，被研究用于预防骨髓基质D1细胞脂肪生成的有益作用。 的溶剂分配提取物组分可防止分化的D1细胞积累脂质。关键脂肪生成标志物PPARγ、SREBP1c和C/EBPα的表达在mRNA和蛋白质水平均受到抑制。磷酸化的MAPK相关因子ERK、JNK和p-38的蛋白水平受到抑制，表明D1细胞中PPARγ途径相关的脂肪生成受到抑制。正丁醇组分是生物活性物质最有效的组分。 由于存在生物活性黄酮类化合物，可抑制D1骨髓基质细胞的脂肪生成。
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