通过调节CCN2/TGF-β信号通路，非瑟酮在皮肤健康中的有益作用和功能。
Beneficial role and function of fisetin in skin health via regulation of the CCN2/TGF-β signaling pathway.
作者信息
Shon Myung-Soo, Kim Ryeong-Hyeon, Kwon O Jun, Roh Seong-Soo, Kim Gyo-Nam
机构信息
1Department of Food, Nutrition and Biotechnology, Kyungnam University, Changwon, 51767 Korea.
Daegyeong Institute for Regional Industry Evaluation, Daegyeong Institute for Regional Program Evaluation, Daegu, 38542 Korea.
出版信息
Food Sci Biotechnol. 2016 Mar 31;25(Suppl 1):133-141. doi: 10.1007/s10068-016-0110-y. eCollection 2016.
Skin is composed of multiple layers, including the epidermis, dermis, and hypodermis. Although several biological activities of fisetin have been reported, beneficial effects and the functions of fisetin in skin remain unclear. B16F10 melanoma cells, human skin fibroblasts, and 3T3-L1 cells were used to examine the beneficial effects of fisetin in skin health. α-MSH- and IBMX-induced melanosis in B16F10 melanoma cells was inhibited by fisetin treatment, which also enhanced mRNA expression levels of skin fibril-related genes via the CCN2/TGF-β signaling pathway. Decreased intracellular lipid accumulation via down-regulation of transcriptional factors through activation of the CCN2/TGF-β signaling pathway was observed. A novel function of fisetin in skin health via down-regulation of melanosis and adipogenesis, and up-regulation of skin fibril-related genes was observed. Evidence for development of nutri-cosmetics for skin health is presented.
皮肤由多层组成，包括表皮、真皮和皮下组织。尽管已报道了非瑟酮的多种生物学活性，但其在皮肤中的有益作用和功能仍不清楚。使用B16F10黑色素瘤细胞、人皮肤成纤维细胞和3T3-L1细胞来研究非瑟酮对皮肤健康的有益作用。非瑟酮处理可抑制α-MSH和IBMX诱导的B16F10黑色素瘤细胞中的黑色素沉着，其还通过CCN2/TGF-β信号通路增强皮肤纤维相关基因的mRNA表达水平。观察到通过激活CCN2/TGF-β信号通路下调转录因子从而减少细胞内脂质积累。观察到非瑟酮通过下调黑色素沉着和脂肪生成以及上调皮肤纤维相关基因对皮肤健康具有新功能。提出了开发用于皮肤健康的营养化妆品的证据。
Zotero 插件