Immanence IDC Inc, Québec, QC, Canada.
Clinique de Dermatologie St-Joseph, Montréal, QC, Canada.
Clin Cosmet Investig Dermatol. 2014 Feb 20;7:73-88. doi: 10.2147/CCID.S53580. eCollection 2014.
Cellulite is a serious cosmetic concern for most of the 90% of women affected by it.
To assess the clinical efficacy of a complex integral anti-cellulite gel.
This double-blind, randomized, placebo-controlled study involved 44 healthy women, aged 25-55 years. Subjects had a normal to slightly overweight body mass index and presented slight to moderate cellulite on their thighs, buttocks, and/or hips at baseline. Subjects were randomly assigned to either the treated or placebo group and accordingly applied the active product or placebo on their hips, stomach, buttocks, and thighs, twice daily for 3 months. Skin tonicity, orange-peel aspect, and stubborn cellulite were assessed at day 0, 28, 56, and 84. A self-evaluation questionnaire was completed by all volunteers.
At the end of the study, an average of 81% of the subjects applying the active product presented improvement in their cellulite condition versus 32% for the placebo group (all descriptors and sites combined). At day 84, skin tonicity, orange-peel appearance, and stubborn cellulite were improved in a significant manner (P<0.05) over placebo, on all studied areas. Skin tonicity improved on average by +41% for buttocks, +35% for hips, and +31% for thighs. Orange peel appearance was reduced on average by -25% for buttocks, -22% for hips, and -22% for thighs. Stubborn cellulite was reduced on average by -19% for buttocks, -24% for hips, and -22% for thighs. Circumference measurements decreased in a significant manner (P<0.05) over placebo, for the abdomen (average value of -1.1 cm) and thighs (average value of -0.8 cm). The product was well tolerated and perceived by the volunteers themselves as better performing than placebo on all criteria.
All results validate the efficacy of the present integral formulation to significantly reduce signs of cellulite and reshape the silhouette.
橘皮组织是 90%受影响女性的严重美容问题。
评估一种综合积分抗橘皮组织凝胶的临床疗效。
这是一项双盲、随机、安慰剂对照研究，涉及 44 名年龄在 25-55 岁之间的健康女性。受试者的身体质量指数正常或略高，基线时大腿、臀部和/或臀部有轻微到中度的橘皮组织。受试者随机分配到治疗组或安慰剂组，根据情况在臀部、腹部、臀部和大腿上每天使用两次活性产品或安慰剂，持续 3 个月。在第 0、28、56 和 84 天评估皮肤紧密度、橙皮外观和顽固的橘皮组织。所有志愿者都完成了自我评估问卷。
研究结束时，81%使用活性产品的受试者的橘皮组织状况得到改善，而安慰剂组为 32%（所有描述符和部位的总和）。在第 84 天，臀部、臀部和大腿的皮肤紧密度、橙皮外观和顽固的橘皮组织均显著改善（P<0.05）。臀部平均增加 41%，臀部增加 35%，大腿增加 31%。橙皮外观平均减少 25%用于臀部，减少 22%用于臀部，减少 22%用于大腿。臀部平均减少 19%，臀部减少 24%，大腿减少 22%。腹部（平均减少 1.1 厘米）和大腿（平均减少 0.8 厘米）的周长测量值显著减少（P<0.05）。该产品耐受性良好，志愿者自己认为与安慰剂相比，该产品在所有标准上的表现都更好。
所有结果均证实了本综合配方显著减少橘皮组织迹象和重塑轮廓的功效。
