大鼠巨噬细胞样细胞系中胶原酶产生的激活。
Activation of collagenase production in a rat macrophage-like cell line.
作者信息
Khar A
出版信息
Biochem Int. 1986 Oct;13(4):565-70.
PMID:3026397
Abstract
Collagenase activity from a rat macrophage line, AK-5, has been studied. The enzyme is present in these cells and its release is stimulated by Con A, LPS and a lymphokine preparation from rat spleen cells. Collagenase activity from these cells is inhibited by EDTA, cysteine or dithiothreitol, thereby suggesting it to be similar to other mammalian collagenases.
摘要
对大鼠巨噬细胞系AK-5的胶原酶活性进行了研究。该酶存在于这些细胞中，其释放受到刀豆球蛋白A、脂多糖和大鼠脾细胞的淋巴因子制剂的刺激。这些细胞的胶原酶活性受到乙二胺四乙酸、半胱氨酸或二硫苏糖醇的抑制，因此表明它与其他哺乳动物胶原酶相似。
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