沙利度胺对人多形核白细胞和血小板中花生四烯酸代谢的影响。
The effect of thalidomide on arachidonic acid metabolism in human polymorphonuclear leukocytes and platelets.
作者信息
Maurice P D, Barkley A S, Allen B R
出版信息
Br J Dermatol. 1986 Dec;115(6):677-80. doi: 10.1111/j.1365-2133.1986.tb06648.x.
Abstract
The effect of thalidomide on the metabolism of arachidonic acid by purified washed human platelets and polymorphonuclear leukocytes was examined. The drug was found to be without effect under the conditions used. The action of thalidomide cannot therefore be attributed to a direct inhibition of prostaglandin or leukotriene biosynthesis.
摘要
研究了沙利度胺对纯化的洗涤人血小板和多形核白细胞中花生四烯酸代谢的影响。发现在所用条件下该药物无作用。因此，沙利度胺的作用不能归因于对前列腺素或白三烯生物合成的直接抑制。
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