City of Helsinki, Department of Social Services and Health Care, POB 6420, 00099, Helsinki, Finland.
Department of Oral Kinesiology, Academic Centre for Dentistry Amsterdam (ACTA), Research Institute MOVE, University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands.
Sleep Breath. 2019 Jun;23(2):531-534. doi: 10.1007/s11325-018-1728-1. Epub 2018 Sep 27.
The aim was to analyze whether or not weight gain influences the treatment outcome of patients with obstructive sleep apnea (OSA) treated with mandibular advancement devices (MAD).
As a part of a follow-up study among OSA patients treated with MAD in primary oral health care, a group of 28 patients reporting worsening of daytime or nighttime symptoms of OSA was given closer examination. Altogether, 21 subjects had a complete set of recordings and were enrolled into the study.
Only three subjects had lost weight during the study period. The mean weight gain of 3.6 kg ± 7.1 kg was significant (p = 0.035). According to linear regression, weight gain was independently significantly associated with lower mean peripheral oxygen saturation 92.4 (SD 1.8 (% per hour) (p = 0.019)) and lowest oxygen saturation 80.1 (SD 7.2 (%) (p = 0.024)) scores.
Weight gain is detrimentally associated with MAD treatment in patients with OSA. These findings suggest that regular follow-up by an experienced dentist is advisable to assess for possible worsening of OSA. Patient support to encourage weight control may be an important adjunct to MAD treatment for OSA.
分析体重增加是否会影响接受下颌前伸装置（MAD）治疗的阻塞性睡眠呼吸暂停（OSA）患者的治疗效果。
作为在初级口腔保健中接受 MAD 治疗的 OSA 患者随访研究的一部分，对报告 OSA 日间或夜间症状恶化的 28 名患者进行了更密切的检查。共有 21 名患者有完整的记录并被纳入研究。
只有 3 名患者在研究期间体重减轻。体重增加 3.6 公斤±7.1 公斤，具有统计学意义（p=0.035）。根据线性回归，体重增加与平均外周血氧饱和度 92.4（SD 1.8（%/小时）（p=0.019））和最低血氧饱和度 80.1（SD 7.2（%）（p=0.024））的下降显著相关。
体重增加与 OSA 患者的 MAD 治疗效果呈负相关。这些发现表明，经验丰富的牙医定期进行随访以评估 OSA 可能恶化的情况是明智的。鼓励控制体重的患者支持可能是 MAD 治疗 OSA 的重要辅助手段。
