Bai Ming-Jian, Feng Jing, Liang Guo-Wei
Department of Clinical Laboratory, Aerospace Central Hospital, Beijing 100049, China.
Chin Med Sci J. 2018 Sep 20;33(3):152-159. doi: 10.24920/11814.
Objective To determine whether urinary myeloperoxidase to creatinine ratio (MCR) can serve as a marker for diagnosis of urinary tract infection (UTI).Methods Patients suspected of UTI were consecutively enrolled and further divided into the culture positive and the sterile groups according to urine culture results. Subsequently, MCR, white blood cell (WBC) and bacteria in the urinary samples from patients were detected and compared between the two groups.Results Finally, 253 patients were enrolled including 157 urine culture positive patients and 96 urine culture negative patients (sterile group). After logarithmic transformation in 2 as the base, the MCR, WBC, and bacteria were separately presented as log , log (quantitative) , and log . The values of log (8.6±2.5 vs. 5.4±1.5, t=-12.453, P=0.001), log (quantitative) (8.0±2.5 vs. 5.2±1.8, t=-10.332, P=0.001), log (11.4±2.5 vs. 8.2±2.8, t=-9.297, P=0.001) and WBC (semi-quantitative) [2 (interquartile range 1, 3) vs. 1 (interquartile range 0.5, 1), Z=-7.580, P=0.001] showed significant difference between the urine culture positive group and the sterile group. Among the urine culture positive group, the values of log of the gram positive and gram negative subgroups were 7.2±2.5 and 9.0±2.4 (t=4.016, P=0.001), respectively. The correlation between log and log (quantitative), log , WBC (semi-quantitative) was 0.708 (Pearson correlation, P=0.001), 0.381 (Pearson correlation, P=0.001), and 0.606 (Spearman correlation, P=0.001), respectively. Conclusions MCR is positively correlated with WBC counts and could be served as a promising biomarker for diagnosis of UTI. MCR could be even used for initial inference of infectious bacteria types of UTI.
目的 确定尿髓过氧化物酶与肌酐比值（MCR）是否可作为诊断尿路感染（UTI）的标志物。方法 连续纳入疑似UTI的患者，并根据尿培养结果进一步分为培养阳性组和无菌组。随后，检测患者尿样中的MCR、白细胞（WBC）和细菌，并在两组之间进行比较。结果 最终纳入253例患者，其中尿培养阳性患者157例，尿培养阴性患者96例（无菌组）。以2为底进行对数转换后，MCR、WBC和细菌分别表示为log₂、log₂（定量）和log₂。log₂（8.6±2.5对5.4±1.5，t=-12.453，P=0.001）、log₂（定量）（8.0±2.5对5.2±1.8，t=-10.332，P=0.001）、log₂（11.4±2.5对8.2±2.8，t=-9.297，P=0.001）和WBC（半定量）[2（四分位数间距1，3）对1（四分位数间距0.5，1），Z=-7.580，P=0.001]在尿培养阳性组和无菌组之间存在显著差异。在尿培养阳性组中，革兰阳性和革兰阴性亚组的log₂值分别为7.2±2.5和9.0±2.4（t=4.016，P=0.001）。log₂与log₂（定量）、log₂、WBC（半定量）的相关性分别为0.708（Pearson相关性，P=0.001）、0.381（Pearson相关性，P=0.001）和0.606（Spearman相关性，P=0.001）。结论 MCR与WBC计数呈正相关，可作为诊断UTI的有前景的生物标志物。MCR甚至可用于初步推断UTI的感染细菌类型。
