儿童和青少年非酒精性肝病。
Nonalcoholic Liver Disease in Children and Adolescents.
机构信息
Department of Pediatric Gastroenterology, Hepatology, and Nutrition, University of California, San Francisco, 550 16th Street, 5th Floor, Mail Code 0136, San Francisco, CA 94143, USA.
Department of Pediatric Gastroenterology, Hepatology, and Nutrition, University of California, San Francisco, 550 16th Street, 5th Floor, Mail Code 0136, San Francisco, CA 94143, USA.
出版信息
Clin Liver Dis. 2018 Nov;22(4):723-733. doi: 10.1016/j.cld.2018.07.001. Epub 2018 Aug 22.
Pediatric nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver disease in children. The spectrum of NAFLD ranges from steatosis to nonalcoholic steatohepatitis (NASH) to fibrosis. Obesity rates in children continue to rise and, as a result, NAFLD in children is becoming more prevalent. The pathophysiology, natural history, and progression of disease are still being elucidated but NAFLD/NASH in children may represent a more severe phenotype that will benefit from early identification and management.
儿科非酒精性脂肪性肝病 (NAFLD) 是儿童最常见的肝病病因。NAFLD 的范围从脂肪变性到非酒精性脂肪性肝炎 (NASH) 再到纤维化。儿童肥胖率持续上升，因此，儿童 NAFLD 越来越普遍。其病理生理学、自然史和疾病进展仍在阐明中，但儿童的 NAFLD/NASH 可能代表一种更严重的表型，将受益于早期识别和管理。
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