Section of Advanced Heart Failure and Transplant, Division of Cardiology, Department of Medicine, University of Colorado Denver, 12631 East 17th Avenue, Aurora, CO 80045, USA.
Advanced Heart Failure and Cardiac Transplantation, St. Vincent Medical Group, 8333 Naab Road, Suite 400, Indianapolis, IN 46260, USA.
Heart Fail Clin. 2018 Oct;14(4):537-543. doi: 10.1016/j.hfc.2018.06.003. Epub 2018 Aug 18.
Iron deficiency anemia is both a comorbid condition and an indicator of poor prognosis in heart failure. The mechanisms by which this occurs are multiple and complex. Recent robust randomized clinical trials have shown significant improvements in quality of life and rates of hospitalization with intravenous repletion of iron. In this article, we review the mechanisms by which iron deficiency impacts heart failure and the evidence behind repletion. There remains a good deal to learn about long-term effects of intravenous iron repletion, and clinical trials are ongoing in this regard.
缺铁性贫血既是心力衰竭的合并症，也是预后不良的指标。发生这种情况的机制是多方面且复杂的。最近的几项强有力的随机临床试验表明，静脉补充铁可显著改善生活质量和住院率。本文综述了缺铁对心力衰竭的影响及其补充的证据。关于静脉铁补充的长期效果，我们还有很多需要了解，这方面的临床试验正在进行中。
