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臂丛神经产瘫的当前流行病学及相关危险因素评估

Assessment of Current Epidemiology and Risk Factors Surrounding Brachial Plexus Birth Palsy.

作者信息

Abzug Joshua M, Mehlman Charles T, Ying Jun

机构信息

Department of Orthopaedics, University of Maryland School of Medicine, Timonium, MD.

Department of Orthopaedics, University of Cincinnati College of Medicine, Cincinnati, OH.

出版信息

J Hand Surg Am. 2019 Jun;44(6):515.e1-515.e10. doi: 10.1016/j.jhsa.2018.07.020. Epub 2018 Sep 25.

Abstract

PURPOSE

Brachial plexus birth palsy (BPBP) is common; however, the current incidence is unknown and more than 50% of infants with BPBP have no known risk factors. The purpose of this study was to determine the current incidence of BPBP, assess known risk factors, and evaluate hypotonia as a new risk factor, as well as estimate the length of stay (LOS) and direct costs of children with an associated BPBP injury.

METHODS

Data from the 1997 to 2012 Kids' Inpatient Database data sets were evaluated to identify patients with a BPBP injury and various risk factors. Evaluation of LOS data and direct costs was also performed. Multivariable logistic regression analysis was utilized to assess the association of BPBP with its known and previously undescribed risk factors.

RESULTS

The incidence of BPBP has steadily decreased from 1997 to 2012, with an incidence of 0.9 ± 0.01 per 1,000 live births recorded in 2012. Shoulder dystocia is the number 1 risk factor for the development of a BPBP injury. Hypotonia is a newly recognized risk factor for the development of BPBP. Fifty-five percent of infants with BPBP have no known perinatal risk factors. The initial hospital LOS is approximately 20% longer for children with a BPBP injury and the hospital stay direct costs are approximately 40% higher.

CONCLUSIONS

The incidence of BPBP is decreasing over time. Shoulder dystocia continues to be the most common risk factor for sustaining a BPBP injury. Children with a BPBP injury have longer LOSs and hospital direct costs compared with children without a BPBP injury.

TYPE OF STUDY/LEVEL OF EVIDENCE: Prognostic II.

摘要

目的

臂丛神经产瘫(BPBP)很常见;然而,目前的发病率尚不清楚,超过50%的BPBP患儿没有已知的风险因素。本研究的目的是确定BPBP的当前发病率,评估已知的风险因素,并将肌张力减退作为一个新的风险因素进行评估,同时估计伴有BPBP损伤儿童的住院时间(LOS)和直接费用。

方法

对1997年至2012年儿童住院数据库数据集的数据进行评估,以确定患有BPBP损伤和各种风险因素的患者。还对LOS数据和直接费用进行了评估。采用多变量逻辑回归分析来评估BPBP与其已知和先前未描述的风险因素之间的关联。

结果

1997年至2012年期间,BPBP的发病率稳步下降,2012年记录的发病率为每1000例活产中有0.9±0.01例。肩难产是BPBP损伤发生的首要风险因素。肌张力减退是BPBP发生的一个新认识到的风险因素。55%的BPBP患儿没有已知的围产期风险因素。BPBP损伤患儿的初始住院LOS大约长20%,住院直接费用大约高40%。

结论

随着时间的推移,BPBP的发病率在下降。肩难产仍然是导致BPBP损伤的最常见风险因素。与没有BPBP损伤的儿童相比,BPBP损伤患儿的LOS更长,住院直接费用更高。

研究类型/证据水平:预后性研究II级

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