基于地中海饮食和 DASH 饮食的饮食模式与 PCaP 中侵袭性前列腺癌呈负相关。

Dietary patterns based on the Mediterranean diet and DASH diet are inversely associated with high aggressive prostate cancer in PCaP.

机构信息

Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC.

Winthrop P Rockefeller Cancer Institute and College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR.

出版信息

Ann Epidemiol. 2019 Jan;29:16-22.e1. doi: 10.1016/j.annepidem.2018.08.012. Epub 2018 Sep 5.

DOI:10.1016/j.annepidem.2018.08.012

PMID:30268488

Abstract

BACKGROUND

Several foods and nutrients have been linked to the development of prostate cancer, but the association between healthy dietary patterns and prostate cancer aggressiveness is less studied. The aim of this study was to evaluate the relationship between the Mediterranean diet (MED) and Dietary Approaches to Stop Hypertension (DASH) diet scores and prostate cancer aggressiveness by race.

METHODS

Data from the population-based, case-only North Carolina-Louisiana Prostate Cancer Project (PCaP) were used to examine the association between diet quality, measured by MED and DASH scores, and prostate cancer aggressiveness in 1899 African American (AA) and European American (EA) research subjects. Dietary intake was assessed using a modified National Cancer Institute Diet History Questionnaire. Logistic regression was used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for high versus low-intermediate aggressive prostate cancer.

RESULTS

Higher MED scores were inversely associated with high aggressive prostate cancer overall (OR: 0.66; 95% CI: 0.46, 0.95 for high versus low scores); results were similar for AA and EA men. A weaker inverse association between DASH scores and prostate cancer aggressiveness was found (OR: 0.76; 95% CI: 0.55, 1.06).

CONCLUSIONS

Higher diet quality, as represented by a Mediterranean-style diet or DASH diet, may reduce the odds of high aggressive prostate cancer.

摘要

背景

一些食物和营养素与前列腺癌的发生有关，但健康饮食模式与前列腺癌侵袭性之间的关联研究较少。本研究旨在评估地中海饮食（MED）和停止高血压的饮食方法（DASH）饮食评分与种族之间前列腺癌侵袭性的关系。

方法

利用基于人群的、仅病例的北卡罗来纳州-路易斯安那前列腺癌计划（PCaP）的数据，检查了通过 MED 和 DASH 评分衡量的饮食质量与 1899 名非裔美国人和欧洲裔美国人（EA）研究对象中前列腺癌侵袭性之间的关联。饮食摄入通过改良的国家癌症研究所饮食史问卷进行评估。使用逻辑回归来估计高 versus 低侵袭性前列腺癌的调整后比值比（OR）和 95%置信区间（CI）。