Department of Biochemistry, Bengaluru, 560012, India; Molecular Biophysics Unit, Indian Institute of Science, Bengaluru, 560012, India; Centre for DNA Fingerprinting and Diagnostics, Hyderabad, 500007, India.
Molecular Biophysics Unit, Indian Institute of Science, Bengaluru, 560012, India; Department of Cell Biology and Molecular Genetics, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, 563101, India.
Biochem Biophys Res Commun. 2018 Oct 28;505(2):445-447. doi: 10.1016/j.bbrc.2018.09.141. Epub 2018 Sep 27.
The bridging element for electron transfer in proteins is the hydrogen bond according to the new experimental perspective in preference to carbon-carbon σ-bond presently used. The purpose of this study is to identify an alternative pathway linked by hydrogen bonds suitable for electron transfer from heme-Fe of cytochrome c to subunit II-CuA of cytochrome a. A pathway consisting of 15 delocalized electron systems including peptide bonds, 5 polar groups of side chains of amino acid residues and 8 water molecules, linked by 27 hydrogen bonds, exists between the two metal electron centers of heme-Fe of cytochrome c, cytochrome c and of subunit II-CuA of cytochrome a. Pathways built of delocalized π-electron systems, polar groups and water molecules linked by hydrogen bonds may be considered for intramolecular and intermolecular electron transfer in proteins.
根据新的实验观点，蛋白质中电子转移的桥接元素是氢键，而不是目前使用的碳-碳 σ 键。本研究的目的是确定一种替代的氢键连接途径，该途径适合将电子从细胞色素 c 的血红素-Fe 转移到细胞色素 a 的亚基 II-CuA。在细胞色素 c 的血红素-Fe、细胞色素 c 和细胞色素 a 的亚基 II-CuA 的两个金属电子中心之间，存在一条由 15 个离域电子系统（包括肽键、5 个氨基酸残基侧链的极性基团和 8 个水分子）组成的途径，由 27 个氢键连接。由离域π电子系统、极性基团和氢键连接的水分子组成的途径可用于蛋白质中的分子内和分子间电子转移。
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