持续存在的肺部亚实性结节的自然病史：不同间隔生长的长期观察。

Natural History of Persistent Pulmonary Subsolid Nodules: Long-Term Observation of Different Interval Growth.

机构信息

Division of Thoracic Surgery, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan.

Physical Examination Center, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

出版信息

Heart Lung Circ. 2019 Nov;28(11):1747-1754. doi: 10.1016/j.hlc.2018.08.015. Epub 2018 Sep 14.

DOI:10.1016/j.hlc.2018.08.015

PMID:30268516

Abstract

BACKGROUND

The long-term natural course and outcomes of subsolid nodules (SSNs) in terms of true growth, substantial growth, and stage shift need to be clarified.

METHODS

Between 2002 and 2016, 128 subjects with persistent SSNs of 3cm or smaller were enrolled. The baseline and interval changes in the series computed tomography (CT) findings during the follow-up period were subsequently reviewed.

RESULTS

The mean follow-up period was 3.57±2.93years. The cumulative percentage of growth nodules of the part-solid nodule (PSN) group was significantly higher than that of the ground-glass nodule (GGN) group by Kaplan-Meier estimation (all p<0.0001). For true SSN growth, GGNs usually take a median follow-up of 7 years to grow; PSNs usually take a median follow-up of 3 years to grow. For substantial SSN growth, GGNs usually take a median follow-up of 9 years to grow; PSNs usually take a median follow-up of 3 years to grow. For stage shift, GGNs usually take a median follow-up of 12 years to grow; PSNs usually take a median follow-up of 9 years to grow.

CONCLUSIONS

The natural course in terms of true growth, substantial growth, and stage shift differed significantly according to their nodule type, which could contribute to the development of follow-up guidelines and management strategy of pulmonary SSNs.

摘要

背景

需要明确亚实性结节（SSN）在真正生长、实质性生长和分期转变方面的长期自然病程和结局。

方法

2002 年至 2016 年间，共纳入 128 例持续存在 3cm 或更小的亚实性结节的患者。随后回顾了随访期间系列计算机断层扫描（CT）检查结果的基线和间隔变化。

结果

平均随访时间为 3.57±2.93 年。Kaplan-Meier 估计显示，部分实性结节（PSN）组的生长结节累积百分比明显高于磨玻璃结节（GGN）组（均<0.0001）。对于真正的 SSN 生长，GGN 通常需要中位随访 7 年才能生长；PSN 通常需要中位随访 3 年才能生长。对于实质性 SSN 生长，GGN 通常需要中位随访 9 年才能生长；PSN 通常需要中位随访 3 年才能生长。对于分期转变，GGN 通常需要中位随访 12 年才能生长；PSN 通常需要中位随访 9 年才能生长。