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钙对心肌肌膜中（钠+钾）-ATP酶结构-功能关系的影响。

Effect of calcium on the structure-function relationship of (Na+ + K+)-ATPase in cardiac sarcolemma.

作者信息

Vrbjar N, Breier A, Ziegelhöffer A, Dzurba A, Soós J

出版信息

Gen Physiol Biophys. 1986 Oct;5(5):545-9.

PMID:3026889
Abstract

Calcium-induced changes in (Na+ + K+)-ATPase activity and structural changes of membrane bound proteins in rat heart sarcolemma were investigated. Increasing concentrations of Ca2+ (0.1-8.0 mmol.l-1) gradually inhibited the (Na+ + K+)-ATPase activity and decreased the alpha-helix content of sarcolemmal proteins. Mathematical and graphical analysis of observed data yielded a quantitative relationship between Ca2+-induced changes in (Na+ + K+)-ATPase activity and the secondary structure of membrane proteins in cardiac sarcolemma.

摘要

研究了钙诱导的大鼠心脏肌膜中（Na+ + K+）-ATP酶活性变化以及膜结合蛋白的结构变化。增加Ca2+浓度（0.1 - 8.0 mmol·l-1）会逐渐抑制（Na+ + K+）-ATP酶活性，并降低肌膜蛋白的α-螺旋含量。对观察数据进行数学和图形分析，得出了钙诱导的（Na+ + K+）-ATP酶活性变化与心脏肌膜中膜蛋白二级结构之间的定量关系。

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Effect of calcium on the structure-function relationship of (Na+ + K+)-ATPase in cardiac sarcolemma.钙对心肌肌膜中（钠+钾）-ATP酶结构-功能关系的影响。
Gen Physiol Biophys. 1986 Oct;5(5):545-9.
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Quantitative relationship between the protein secondary structure in cardiac sarcolemma and the activity of the membrane-bound Ca2+-ATPase.心肌肌膜蛋白二级结构与膜结合钙ATP酶活性之间的定量关系。
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