电刺激梨状皮层治疗癫痫：支持证据综述
Electrical stimulation of the piriform cortex for the treatment of epilepsy: A review of the supporting evidence.
作者信息
Young James C, Vaughan David N, Paolini Antonio G, Jackson Graeme D
机构信息
The Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, 245 Burgundy Street, Heidelberg, Victoria 3084, Australia; Florey Department of Neuroscience and Mental Health, The University of Melbourne, Melbourne, 30 Royal Parade, Parkville, Victoria 3052, Australia.
The Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, 245 Burgundy Street, Heidelberg, Victoria 3084, Australia; Florey Department of Neuroscience and Mental Health, The University of Melbourne, Melbourne, 30 Royal Parade, Parkville, Victoria 3052, Australia; Department of Neurology, Austin Health, Melbourne, 145 Studley Road, Heidelberg, Victoria 3084, Australia.
出版信息
Epilepsy Behav. 2018 Nov;88:152-161. doi: 10.1016/j.yebeh.2018.09.004. Epub 2018 Sep 27.
In this review, we consider how the piriform cortex is engaged in both focal and generalized epilepsy networks and postulate the various neural pathways that can be effectively neuromodulated by stimulation at this site. This highlights the common involvement of the piriform cortex in epilepsy. We address both current and future preclinical studies of deep brain stimulation (DBS) of the piriform cortex, with attention to the critical features of these trials that will enable them to be of greatest utility in informing clinical translation. Although recent DBS trials have utilized thalamic targets, electrical stimulation of the piriform cortex may also be a useful intervention for people with epilepsy. However, more work is required to develop a solid foundation for this approach before considering human trials.
在本综述中，我们探讨梨状皮质如何参与局灶性和全身性癫痫网络，并推测通过该部位刺激可有效进行神经调节的各种神经通路。这突出了梨状皮质在癫痫中的共同参与。我们讨论了当前和未来对梨状皮质进行深部脑刺激（DBS）的临床前研究，关注这些试验的关键特征，这些特征将使其在为临床转化提供信息方面发挥最大作用。尽管最近的DBS试验采用了丘脑靶点，但对癫痫患者而言，梨状皮质的电刺激也可能是一种有用的干预措施。然而，在考虑人体试验之前，需要开展更多工作来为这种方法奠定坚实基础。
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