Ochoa-Lantigua Pamela, Moreira-Mendoza Jhinson, García Ríos Cecilia Alejandra, Rodas Jose A, Leon-Rojas Jose E
NeurALL Research Group, Quito 170157, Ecuador.
Facultad Ciencias de la Salud, Universidad Nacional de Chimborazo (UNACH), Riobamba 060108, Ecuador.
Diagnostics (Basel). 2024 Dec 17;14(24):2838. doi: 10.3390/diagnostics14242838.
The piriform cortex (PC) plays a pivotal role in the onset and propagation of temporal lobe epilepsy (TLE), making it a potential target for therapeutic interventions. This review delves into the anatomy and epileptogenic connections of the PC, highlighting its significance in seizure initiation and resistance to pharmacological treatments. Despite its importance, the PC remains underexplored in surgical approaches for TLE. We examine the specific neuroanatomy of the PC as well as the limitations of current imaging techniques and surgical interventions, emphasizing the need for improved imaging protocols to safely target the PC, especially in minimally invasive procedures. Furthermore, the PC's proximity to vital structures, such as the lenticulostriate arteries, presents challenges that must be addressed in future research. By developing multimodal imaging techniques and refining surgical strategies, the PC could emerge as a crucial node in improving seizure freedom outcomes for TLE patients.
梨状皮层（PC）在颞叶癫痫（TLE）的发作和传播中起关键作用，使其成为治疗干预的潜在靶点。本综述深入探讨了PC的解剖结构和致痫连接，强调了其在癫痫发作起始和对药物治疗耐药性方面的重要性。尽管PC很重要，但在TLE的手术治疗中仍未得到充分探索。我们研究了PC的具体神经解剖结构以及当前成像技术和手术干预的局限性，强调需要改进成像方案以安全地靶向PC，特别是在微创手术中。此外，PC靠近重要结构，如豆纹动脉，这带来了必须在未来研究中解决的挑战。通过开发多模态成像技术和完善手术策略，PC可能成为改善TLE患者无癫痫发作结局的关键节点。
