长链非编码 RNA HULC 影响间充质干细胞的增殖、凋亡、迁移和侵袭。
Long non-coding RNA HULC affects the proliferation, apoptosis, migration, and invasion of mesenchymal stem cells.
机构信息
1 Department of Obstetrics and Gynecology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
2 The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School, Nanjing University, Nanjing 210093, China.
出版信息
Exp Biol Med (Maywood). 2018 Sep;243(13):1074-1082. doi: 10.1177/1535370218804781. Epub 2018 Sep 30.
Exploring the molecular mechanisms of growth and function in MSCs is the key to improve their clinical therapeutic effects. Currently, more and more evidence show that the long non-coding RNA (lncRNA) plays an important role in the growth, stemness and function of MSCs.Both HULC and MALAT1 are the earliest discovered LNCRNAs, which are closely related to tumor growth. All of them can promote the growth of liver cancer stem cells. Previously, we have studied the effects of MALAT1 on the growth and function of MSCs. In this study, we focused on the effects of HULC on MSCs. We elucidated the effects of HULC on the growth and differentiation of MSCs, and explored the relationship between inflammatory stimuli and HULC expression in MSCs. Our findings provide a new molecular target for the growth and clinical application of MSCs.
探究间充质干细胞生长和功能的分子机制是提高其临床治疗效果的关键。目前，越来越多的证据表明，长链非编码 RNA（lncRNA）在间充质干细胞的生长、干性和功能中发挥着重要作用。HULC 和 MALAT1 都是最早发现的与肿瘤生长密切相关的 lncRNA，它们都能促进肝癌干细胞的生长。之前，我们已经研究了 MALAT1 对间充质干细胞生长和功能的影响。在这项研究中，我们专注于 HULC 对间充质干细胞的影响。我们阐明了 HULC 对间充质干细胞生长和分化的影响，并探讨了间充质干细胞中炎症刺激与 HULC 表达之间的关系。我们的研究结果为间充质干细胞的生长和临床应用提供了新的分子靶点。
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