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Insertions of resistance genes into Tn21-like transposons.

作者信息

Wiedemann B, Meyer J F, Zühlsdorf M T

出版信息

J Antimicrob Chemother. 1986 Oct;18 Suppl C:85-92. doi: 10.1093/jac/18.supplement_c.85.

DOI:10.1093/jac/18.supplement_c.85
PMID:3027019
Abstract

The evolution of Tn21 and related multiresistance transposons of natural and artificial origin is described. Variations resulting from insertions and deletions in these transposons indicate the presence of specific recombination sites. There is evidence that these 'hot spots' are flanking several resistance genes. We examined these structures on the basis of the aadA gene, mediating resistance to spectinomycin and streptomycin. Comparison of the DNA sequences of Tn21, Tn7 and pSa indicate the wide spread of these recombination sites.

摘要

相似文献

1
Insertions of resistance genes into Tn21-like transposons.
J Antimicrob Chemother. 1986 Oct;18 Suppl C:85-92. doi: 10.1093/jac/18.supplement_c.85.
2
Site-specific integration of genes into hot spots for recombination flanking aadA in Tn21 transposons.基因在Tn21转座子中aadA侧翼重组热点的位点特异性整合。
Mol Gen Genet. 1991 Sep;229(1):137-46. doi: 10.1007/BF00264222.
3
Structure and function of hot spots providing signals for site-directed specific recombination and gene expression in Tn21 transposons.
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4
Precise insertion of antibiotic resistance determinants into Tn21-like transposons: nucleotide sequence of the OXA-1 beta-lactamase gene.抗生素抗性决定簇精确插入Tn21样转座子：OXA-1β-内酰胺酶基因的核苷酸序列
Proc Natl Acad Sci U S A. 1987 Nov;84(21):7378-82. doi: 10.1073/pnas.84.21.7378.
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Functional and physiological characterization of the Tn21 cassette for resistance genes in Tn2426.Tn2426中抗性基因的Tn21盒的功能和生理学特征
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The region of the IncN plasmid R46 coding for resistance to beta-lactam antibiotics, streptomycin/spectinomycin and sulphonamides is closely related to antibiotic resistance segments found in IncW plasmids and in Tn21-like transposons.IncN 质粒 R46 中编码对β-内酰胺类抗生素、链霉素/壮观霉素和磺胺类药物耐药性的区域，与在 IncW 质粒和 Tn21 样转座子中发现的抗生素耐药片段密切相关。
Nucleic Acids Res. 1987 Sep 25;15(18):7491-501. doi: 10.1093/nar/15.18.7491.
7
Structural and functional characterization of tnpI, a recombinase locus in Tn21 and related beta-lactamase transposons.Tn21及相关β-内酰胺酶转座子中重组酶基因座tnpI的结构与功能特性
J Bacteriol. 1990 Jul;172(7):3745-57. doi: 10.1128/jb.172.7.3745-3757.1990.
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The dhfrI trimethoprim resistance gene of Tn7 can be found at specific sites in other genetic surroundings.Tn7的二氢叶酸还原酶I甲氧苄啶抗性基因可在其他遗传环境的特定位点找到。
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9
On the evolution of Tn21-like multiresistance transposons: sequence analysis of the gene (aacC1) for gentamicin acetyltransferase-3-I(AAC(3)-I), another member of the Tn21-based expression cassette.关于Tn21样多抗性转座子的进化：基于Tn21的表达盒的另一个成员——庆大霉素乙酰转移酶-3-I（AAC(3)-I）基因（aacC1）的序列分析
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Plasmid. 1987 Nov;18(3):246-9. doi: 10.1016/0147-619x(87)90067-9.

引用本文的文献

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Front Microbiol. 2018 Sep 21;9:2066. doi: 10.3389/fmicb.2018.02066. eCollection 2018.
2
IntI2 integron integrase in Tn7.Tn7中的IntI2整合子整合酶
J Bacteriol. 2002 Mar;184(6):1712-21. doi: 10.1128/JB.184.6.1712-1721.2002.
3
Transposon Tn21, flagship of the floating genome.转座子Tn21，流动基因组的标志。
Microbiol Mol Biol Rev. 1999 Sep;63(3):507-22. doi: 10.1128/MMBR.63.3.507-522.1999.
4
The 3' conserved segment of integrons contains a gene associated with multidrug resistance to antiseptics and disinfectants.整合子的3'保守区段含有一个与对防腐剂和消毒剂的多药耐药性相关的基因。
Antimicrob Agents Chemother. 1993 Apr;37(4):761-8. doi: 10.1128/AAC.37.4.761.
5
A novel dihydrofolate reductase cassette inserted in an integron borne on a Tn21-like element.一个插入在类Tn21元件携带的整合子中的新型二氢叶酸还原酶盒。
Antimicrob Agents Chemother. 1993 Jun;37(6):1297-304. doi: 10.1128/AAC.37.6.1297.
6
Integrons: novel DNA elements which capture genes by site-specific recombination.整合子：通过位点特异性重组捕获基因的新型DNA元件。
Genetica. 1993;90(2-3):115-32. doi: 10.1007/BF01435034.
7
Cloning and characterization of a 3-N-aminoglycoside acetyltransferase gene, aac(3)-Ib, from Pseudomonas aeruginosa.从铜绿假单胞菌中克隆并鉴定3-N-氨基糖苷乙酰转移酶基因aac(3)-Ib
Antimicrob Agents Chemother. 1995 Aug;39(8):1790-6. doi: 10.1128/AAC.39.8.1790.
8
Site-specific recombination promotes linkage between trimethoprim- and sulfonamide resistance genes. Sequence characterization of dhfrV and sulI and a recombination active locus of Tn21.位点特异性重组促进甲氧苄啶抗性基因与磺胺抗性基因之间的连锁。二氢叶酸还原酶V（dhfrV）和磺胺类药物抗性基因I（sulI）的序列特征以及Tn21的一个重组活性位点。
Mol Gen Genet. 1988 Aug;213(2-3):191-201. doi: 10.1007/BF00339581.
9
Precise insertion of antibiotic resistance determinants into Tn21-like transposons: nucleotide sequence of the OXA-1 beta-lactamase gene.抗生素抗性决定簇精确插入Tn21样转座子：OXA-1β-内酰胺酶基因的核苷酸序列
Proc Natl Acad Sci U S A. 1987 Nov;84(21):7378-82. doi: 10.1073/pnas.84.21.7378.
10
The region of the IncN plasmid R46 coding for resistance to beta-lactam antibiotics, streptomycin/spectinomycin and sulphonamides is closely related to antibiotic resistance segments found in IncW plasmids and in Tn21-like transposons.IncN 质粒 R46 中编码对β-内酰胺类抗生素、链霉素/壮观霉素和磺胺类药物耐药性的区域，与在 IncW 质粒和 Tn21 样转座子中发现的抗生素耐药片段密切相关。
Nucleic Acids Res. 1987 Sep 25;15(18):7491-501. doi: 10.1093/nar/15.18.7491.