Science, serendipity, and the single degree.
作者信息
Hobbs Helen H
出版信息
J Clin Invest. 2018 Oct 1;128(10):4218-4223. doi: 10.1172/JCI124404.
Abstract
摘要
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The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation.与脂肪性肝病相关的PNPLA3变体（I148M）通过逃避泛素化作用而在脂滴上积累。
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Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci.肥胖会放大多个基因位点赋予的脂肪肝疾病遗传风险。
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TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content.TM6SF2 是肝脏脂肪代谢的调节因子，影响甘油三酯的分泌和肝内脂滴含量。
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