Beloussov L V
Ontogenez. 2017 Jan-Feb;48(1):4-7.
The laboratory is engaged in morphomechanics—the study of self-organization of mechanical forces that create the shape and structure of the embryonic primordia. As part of its work, the laboratory described pulsating modes of mechanical stresses in hydroids, identified and mapped mechanical stresses in the tissues of amphibian embryos, and studied morphogenetic reorganization caused by the relaxation and reorientation of tensions. The role of mechanical stresses in maintaining the orderly architectonics of the embryo is shown. Mechano-dependent genes are detected. Microstrains of embryonic tissues and stress gradients associated with them are described. A model of hyper-recovery of mechanical stresses as a possible driving force of morphogenesis is proposed.
该实验室致力于形态力学研究——即研究产生胚胎原基形状和结构的机械力的自组织。作为其工作的一部分,该实验室描述了水螅中机械应力的脉动模式,识别并绘制了两栖动物胚胎组织中的机械应力,并研究了由张力松弛和重新定向引起的形态发生重组。展示了机械应力在维持胚胎有序结构中的作用。检测到了机械依赖基因。描述了胚胎组织的微应变及其相关的应力梯度。提出了机械应力超恢复模型,将其作为形态发生的一种可能驱动力。