Thomas H J, Avery L N, Brockman R W, Montgomery J A
J Med Chem. 1987 Feb;30(2):431-4. doi: 10.1021/jm00385a030.
5-Amino-4-(diazoacetyl)-1-beta-D-ribofuranosylimidazole (15), 5-amino-4-(chloroacetyl)-1-beta-D-ribofuranosylimidazole (16), and a number of related imidazole ribonucleosides have been synthesized. Compounds 15 and 16 are cytotoxic to both H.Ep.-2 and L1210 leukemia cells in culture. The (diazoacetyl)imidazole 15 is also active against the P388 leukemia in mice.
已合成了5-氨基-4-（重氮乙酰基）-1-β-D-呋喃核糖基咪唑（15）、5-氨基-4-（氯乙酰基）-1-β-D-呋喃核糖基咪唑（16）以及许多相关的咪唑核糖核苷。化合物15和16在培养中对H.Ep.-2和L1210白血病细胞均具有细胞毒性。（重氮乙酰基）咪唑15对小鼠的P388白血病也有活性。
