Co-infection of Clostridioides (Clostridium) difficile GMU1 and Bacillus cereus GMU2 in one patient in Guizhou, China.
作者信息
Hong Wei, Cheng Yumei, Rao Fengqin, Yang Jing, Cui Guzhen, Chen Zhenghong, Liao Jian, Huang Xiaolin, Zhang Jie, Wang Pixiang, Wang Shaohua, Wang Yi, Guan Zhizhong, Qi Xiaolan
机构信息
Key Laboratory of Endemic and Ethnic Diseases, Guizhou Medical University, Ministry of Education, Guiyang, 550004, China; Key Laboratory of Medical Molecular Biology, Guizhou Medical University, Guiyang, 550004, China.
Department of Critical Care Medicine, The Affiliate Hospital of Guizhou Medical University, Guiyang, 550004, China.
出版信息
Anaerobe. 2018 Dec;54:159-163. doi: 10.1016/j.anaerobe.2018.08.004. Epub 2018 Sep 28.
Clostridioides (Clostridium) difficile and Bacillus cereus infections are frequently reported in human individually. However, co-infection of both pathogens in human is extremely rare. In the present study, we reported a case of human enteric disease caused by co-infection of C. difficile and B. cereus in Guizhou, China. The 16S rDNA sequencing result showed that C. difficile GMU1 and B. cereus GMU2 were most related to C. difficile ATCC 9689 and B. cereus ATCC 14579. The toxin genotype of C. difficile GMU1 and B. cereus GMU2 were tcdAtcdBtcdC and bceTnheAnheBnheC, respectively. Cytotoxicity assay demonstrated that C. difficile GMU1 produced significantly higher toxin B compare to C. difficile 630 stain. In contrast, B. cereus GMU2 has comparable NheA toxin productivity compare to previous report. The antimicrobial susceptibility test showed that the combination of ampicillin and vancomycin was most efficient to inhibit both C. difficile GMU1 and B. cereus GMU2.
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