Long Guanghui, Zhang Guangtao, Zhang Fangting, Ye Dongshuo, Yang Dengke, Yang Yinke
Clin Lab. 2018 Sep 1;64(9):1357-1361. doi: 10.7754/Clin.Lab.2018.180129.
This study was to investigate the relationship between SLC22A1 and SLC22A4 gene polymorphisms and genetic susceptibility to type 2 diabetes in Chinese Han population.
The research group comprised 110 Chinese Han patients with type 2 diabetes, and the control group included 110 healthy volunteers. The polymorphisms of SLC22A1 gene rs628031 and rs2282143 loci and SLC22A4 gene rs2073838 and rs272893 loci were detected in the two groups.
Statistically significant differences were identified in the genotype distributions of SLC22A1 gene rs628031 and rs2282143 loci between the two groups (p < 0.05). The A allele frequency of SLC22A1 gene rs628031 locus and the T allele frequency of rs2282143 locus were higher in the research group than in the control group (p < 0.05). The genotype distributions of rs272893 locus showed a significant difference between the two groups (p < 0.05), but not SLC22A4 gene rs2073838 locus (p > 0.05).
The polymorphisms of SLC22A1 gene rs628031 and rs2282143 loci and SLC22A4 gene rs272893 locus of patients with type 2 diabetes indicated a significant difference between the two groups, suggesting that these genetic locus mutations increase the risk of type 2 diabetes in Chinese Han patients.
本研究旨在探讨中国汉族人群中溶质载体家族22成员1（SLC22A1）和溶质载体家族22成员4（SLC22A4）基因多态性与2型糖尿病遗传易感性之间的关系。
研究组包括110例中国汉族2型糖尿病患者，对照组包括110名健康志愿者。检测两组中SLC22A1基因rs628031和rs2282143位点以及SLC22A4基因rs2073838和rs272893位点的多态性。
两组之间SLC22A1基因rs628031和rs2282143位点的基因型分布存在统计学显著差异（p<0.05）。研究组中SLC22A1基因rs628031位点的A等位基因频率和rs2282143位点的T等位基因频率高于对照组（p<0.05）。rs272893位点的基因型分布在两组之间存在显著差异（p<0.05），但SLC22A4基因rs2073838位点无显著差异（p>0.05）。
2型糖尿病患者的SLC22A1基因rs628031和rs2282143位点以及SLC22A4基因rs272893位点的多态性在两组之间存在显著差异，表明这些基因位点突变增加了中国汉族患者患2型糖尿病的风险。
