甲硫氨酸亚砜还原酶在大肠杆菌及其他细菌的氧化应激耐受性和毒力中的作用
The Role of Methionine Sulfoxide Reductases in Oxidative Stress Tolerance and Virulence of and Other Bacteria.
作者信息
Singh Vineet K, Singh Kuldeep, Baum Kyle
机构信息
Department of Microbiology and Immunology, A.T. Still University of Health Sciences, Kirksville, MO 63501, USA.
Mayo Clinic, Rochester, MN 53905, USA.
出版信息
Antioxidants (Basel). 2018 Sep 28;7(10):128. doi: 10.3390/antiox7100128.
Abstract
Methionine sulfoxide reductases (MSRA1 and MSRB) are proteins overproduced in during exposure with cell wall-active antibiotics. Later studies identified the presence of two additional MSRA proteins (MSRA2 and MSRA3) in . These MSR proteins have been characterized in many other bacteria as well. This review provides the current knowledge about the conditions and regulatory network that mimic the expression of these MSR encoding genes and their role in defense from oxidative stress and virulence.
摘要
甲硫氨酸亚砜还原酶（MSRA1和MSRB）是在暴露于细胞壁活性抗生素期间过度产生的蛋白质。后来的研究确定在……中还存在另外两种MSRA蛋白（MSRA2和MSRA3）。这些甲硫氨酸亚砜还原酶蛋白在许多其他细菌中也有特征描述。本综述提供了关于模拟这些甲硫氨酸亚砜还原酶编码基因表达的条件和调控网络及其在抵御氧化应激和毒力方面作用的当前知识。
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