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抗巨噬细胞的鼠猴病毒40肿瘤表达一种逆转录病毒型特异性糖蛋白70。

Macrophage-resistant murine simian virus 40 tumors express a retroviral type-specific gp70.

作者信息

Chapes S K, O'Neill A E, Flaherty L, Gooding L R

出版信息

J Virol. 1987 Mar;61(3):928-32. doi: 10.1128/JVI.61.3.928-932.1987.

DOI:10.1128/JVI.61.3.928-932.1987
PMID:3027416
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC254041/
Abstract

Prototype macrophage-resistant and -sensitive cells were subcloned. Among several subclones of the resistant line, one subclone showed partial reversion to a sensitive phenotype. Analysis with monoclonal antibodies specific for different serotypes of endogenous murine leukemia virus revealed that expression of only one such gp70 (gp70a) correlated with the macrophage-resistant phenotype.

摘要

对巨噬细胞抗性和敏感性原型细胞进行了亚克隆。在抗性细胞系的几个亚克隆中，有一个亚克隆表现出部分回复到敏感表型。用针对内源性鼠白血病病毒不同血清型的单克隆抗体进行分析发现，只有一种这样的gp70（gp70a）的表达与巨噬细胞抗性表型相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a653/254041/5dbc2ce312fb/jvirol00094-0301-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a653/254041/03ea3509724e/jvirol00094-0299-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a653/254041/5f5bb6d6cc73/jvirol00094-0299-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a653/254041/2d0be93c8f5c/jvirol00094-0300-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a653/254041/e23b11d21b43/jvirol00094-0300-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a653/254041/5dbc2ce312fb/jvirol00094-0301-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a653/254041/03ea3509724e/jvirol00094-0299-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a653/254041/5f5bb6d6cc73/jvirol00094-0299-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a653/254041/2d0be93c8f5c/jvirol00094-0300-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a653/254041/e23b11d21b43/jvirol00094-0300-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a653/254041/5dbc2ce312fb/jvirol00094-0301-a.jpg

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Characterization of a progressive tumor from C3H fibroblasts transformed in vitro with SV40 virus. Immunoresistance in vivo correlates with phenotypic loss of H-2Kk.对用SV40病毒体外转化的C3H成纤维细胞来源的进展性肿瘤的特征描述。体内免疫抗性与H-2Kk的表型丧失相关。
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Cloning and characterization of the integrated viral DNA from three lines of SV40-transformed mouse cells.来自三株SV40转化小鼠细胞系的整合病毒DNA的克隆与特性分析
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Monoclonal antibodies specific for simian virus 40 tumor antigens.针对猴病毒40肿瘤抗原的单克隆抗体。
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Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
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