抗巨噬细胞的鼠猴病毒40肿瘤表达一种逆转录病毒型特异性糖蛋白70。
Macrophage-resistant murine simian virus 40 tumors express a retroviral type-specific gp70.
作者信息
Chapes S K, O'Neill A E, Flaherty L, Gooding L R
出版信息
J Virol. 1987 Mar;61(3):928-32. doi: 10.1128/JVI.61.3.928-932.1987.
Abstract
Prototype macrophage-resistant and -sensitive cells were subcloned. Among several subclones of the resistant line, one subclone showed partial reversion to a sensitive phenotype. Analysis with monoclonal antibodies specific for different serotypes of endogenous murine leukemia virus revealed that expression of only one such gp70 (gp70a) correlated with the macrophage-resistant phenotype.
摘要
对巨噬细胞抗性和敏感性原型细胞进行了亚克隆。在抗性细胞系的几个亚克隆中，有一个亚克隆表现出部分回复到敏感表型。用针对内源性鼠白血病病毒不同血清型的单克隆抗体进行分析发现，只有一种这样的gp70（gp70a）的表达与巨噬细胞抗性表型相关。
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