克氏锥虫病相关病原体的基因功能发现。
Gene Function Discovery for Kinetoplastid Pathogens.
机构信息
Institute of Parasitology, McGill University, 21111 Lakeshore Road, Ste. Anne de Bellevue, Montreal, Quebec H9X3V9, Canada; McGill Centre for Bioinformatics, McGill University, 3649 Promenade Sir William Osler, Montreal, Quebec H3G0B1, Canada; Department of Biochemistry, McGill University, McIntyre Medical Building, 3655 Promenade Sir William Osler, Montreal, Quebec H3G1Y6, Canada.
Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA.
出版信息
Trends Parasitol. 2019 Jan;35(1):8-12. doi: 10.1016/j.pt.2018.09.003. Epub 2018 Sep 28.
We propose to integrate the existing and new experimental data with computational tools to model interaction networks for the most prominent kinetoplastid pathogens. These interaction networks will vastly expand the functional annotation of the kinetoplastid genomes, which in turn are critical for identifying new routes of disease intervention.
我们建议将现有的和新的实验数据与计算工具相结合，为最主要的动基体目病原体建立相互作用网络模型。这些相互作用网络将极大地扩展动基体目基因组的功能注释，这对于确定新的疾病干预途径至关重要。
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