Suksaeree Jirapornchai, Prasomkij Jessada, Panrat Kamon, Pichayakorn Wiwat
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Rangsit University, Muang, Pathum Thani 12000, Thailand.
Pharmaceutical Laboratory Service Center, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.
Adv Pharm Bull. 2018 Aug;8(3):401-410. doi: 10.15171/apb.2018.047. Epub 2018 Aug 29.
The objective of the present investigation was to prepare and evaluate transdermal patches for nicotine. Pectin isolated from the hulls of Monthong durian or leaves of Krueo Ma Noy was used as a matrix membrane for the controlled release of nicotine and compared with commercial pectin. The mechanical properties, moisture uptake, and Fourier transform infrared spectra were characterized. The in vitro stability of these patches was evaluated and compared to commercial nicotine patches. The mechanical properties of the patches made from isolated pectin were greater than those prepared from commercial pectin; brittle commercial patches were obtained after nicotine loading. The moisture uptake of the patches made with isolated pectin was in the range of 30.20-44.29%. There was no incompatibility between the ingredients of the nicotine transdermal patches or any degradation of the drug. The matrix layer made from isolated pectin controlled the nicotine release more effectively than did commercial nicotine patches. In addition, these patches were stable at in a refrigerator (approximately 4±2 °C) and at ambient temperature (approximately 30±2 °C) for 3 months, retaining 90% of the loaded nicotine. Our study suggests that using isolated pectin as the matrix layer should control the release of nicotine from transdermal patches.
本研究的目的是制备并评估尼古丁透皮贴剂。从金枕头榴莲果壳或Krueo Ma Noy叶片中分离得到的果胶被用作尼古丁控释的基质膜，并与市售果胶进行比较。对其机械性能、吸湿率和傅里叶变换红外光谱进行了表征。评估了这些贴剂的体外稳定性，并与市售尼古丁贴剂进行比较。由分离得到的果胶制成的贴剂的机械性能优于市售果胶制成的贴剂；加载尼古丁后得到易碎的市售贴剂。用分离得到的果胶制成的贴剂的吸湿率在30.20%至44.29%之间。尼古丁透皮贴剂的成分之间不存在不相容性，药物也没有任何降解。由分离得到的果胶制成的基质层比市售尼古丁贴剂更有效地控制尼古丁释放。此外，这些贴剂在冰箱（约4±2℃）和室温（约30±2℃）下稳定3个月，保留90%加载的尼古丁。我们的研究表明，使用分离得到的果胶作为基质层应能控制尼古丁从透皮贴剂中的释放。
