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Starting with a lower daily dose of dasatinib in patients with chronic myeloid leukemia in chronic phase: Less is more, or is it?

作者信息

Eskazan Ahmet Emre

机构信息

Division of Hematology, Department of Internal Medicine, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.

出版信息

Cancer. 2018 Nov 1;124(21):4260-4261. doi: 10.1002/cncr.31682. Epub 2018 Oct 1.

DOI:10.1002/cncr.31682
PMID:30276792
Abstract
摘要

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Starting with a lower daily dose of dasatinib in patients with chronic myeloid leukemia in chronic phase: Less is more, or is it?
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Reply to Starting with a lower daily dose of dasatinib in patients with chronic myeloid leukemia in chronic phase: Less is more, or is it?
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Dasatinib: from treatment of imatinib-resistant or -intolerant patients with chronic myeloid leukemia to treatment of patients with newly diagnosed chronic phase chronic myeloid leukemia.达沙替尼：从治疗对伊马替尼耐药或不耐受的慢性髓性白血病患者到治疗新诊断的慢性期慢性髓性白血病患者。
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The Efficacy of Reduced-dose Dasatinib as a Subsequent Therapy in Patients with Chronic Myeloid Leukemia in the Chronic Phase: The LD-CML Study of the Kanto CML Study Group.低剂量达沙替尼作为慢性期慢性髓性白血病患者后续治疗的疗效：关东慢性髓性白血病研究组的LD-CML研究
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Dasatinib: a tyrosine kinase inhibitor for the treatment of chronic myelogenous leukemia and philadelphia chromosome-positive acute lymphoblastic leukemia.达沙替尼：一种用于治疗慢性粒细胞白血病和费城染色体阳性急性淋巴细胞白血病的酪氨酸激酶抑制剂。
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Dasatinib rapidly induces deep molecular response in chronic-phase chronic myeloid leukemia patients who achieved major molecular response with detectable levels of BCR-ABL1 transcripts by imatinib therapy.达沙替尼可快速诱导伊马替尼治疗后 BCR-ABL1 转录本可检测到的慢性期慢性髓性白血病患者获得主要分子学反应的深层分子反应。
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Low-dose dasatinib: when less can be more.低剂量达沙替尼：少即是多。
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Tyrosine kinase inhibitors (TKIs) used in the management of chronic myeloid leukaemia are associated with haematologic toxicities-Which TKI is the safest?用于治疗慢性髓性白血病的酪氨酸激酶抑制剂（TKIs）与血液学毒性相关 - 哪种TKI最安全？
Br J Clin Pharmacol. 2019 Oct;85(10):2241-2243. doi: 10.1111/bcp.14092. Epub 2019 Aug 22.