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成人创伤性神经损伤管理的最新进展——取代旧观念:综述。

An update on the management of adult traumatic nerve injuries-replacing old paradigms: A review.

机构信息

From the Department of Neurosurgery (B.W.S., J.R.J., L.J.-S.Y.), University of Michigan, Ann Arbor, Michigan; Department of Neurology and Neurological Sciences (S.S.), Department of Surgery (D.A.S.), and Department of Neurosurgery (T.J.W.), Stanford University, Stanford, California.

出版信息

J Trauma Acute Care Surg. 2019 Feb;86(2):299-306. doi: 10.1097/TA.0000000000002081.

Abstract

Acute nerve injuries are routinely encountered in multisystem trauma patients. Advances in surgical treatment of nerve injuries now mean that good outcomes can be achieved. Despite this, old mantras associated with management of nerve injuries, including "wait a year to see if recovery occurs" and "there's nothing we can do", persist. Practicing by these mantras places these patients at a disadvantage. Changes begin to occur in the nerve, neuromuscular junction, and muscle from the moment a nerve injury occurs. These changes can become irreversible approximately 18 to 24 months following denervation. Thus, it is a race to reestablish a functional nerve-muscle connection before these irreversible changes. Good outcomes rely on appropriate acute management and avoiding delays in care. Primary nerve surgery options include direct primary repair, nerve graft repair, and nerve transfer. Acute management of nerve injuries proceeds according to the rule of 3's and requires early cooperation between trauma surgeons who recognize the nerve injury and consultant nerve surgeons. Care of patients with acute traumatic nerve injuries should not be delayed. Awareness of current management paradigms among trauma surgeons will help facilitate optimal upfront management. With the ever-expanding surgical options for management of these injuries and the associated improvement of outcomes, early multidisciplinary approaches to these injuries have never been more important. Old mantras must be replaced with new paradigms to continue to see improvements in outcomes for these patients. The importance of this review is to raise awareness among trauma surgeons of new paradigms for management of traumatic nerve injuries.

摘要

急性神经损伤在多发伤患者中经常遇到。神经损伤的外科治疗进展意味着现在可以获得良好的结果。尽管如此,与神经损伤管理相关的旧观念,包括“等待一年看是否会恢复”和“我们无能为力”,仍然存在。遵循这些旧观念会使这些患者处于不利地位。从神经损伤发生的那一刻起,神经、运动终板和肌肉就开始发生变化。这些变化大约在去神经支配后 18 至 24 个月后变得不可逆转。因此,在这些不可逆转的变化发生之前,重新建立功能神经-肌肉连接是一场竞赛。良好的结果依赖于适当的急性管理和避免护理延误。主要的神经外科手术选择包括直接修复、神经移植修复和神经转移。神经损伤的急性管理遵循“三原则”,需要认识到神经损伤的创伤外科医生与顾问神经外科医生之间的早期合作。不应延误急性创伤性神经损伤患者的治疗。创伤外科医生对当前管理模式的认识将有助于促进最佳的即时管理。随着这些损伤管理的手术选择不断扩大,以及相关结果的改善,早期多学科方法处理这些损伤从未如此重要。必须用新的模式取代旧的模式,才能继续看到这些患者的结果得到改善。本综述的重要性在于提高创伤外科医生对创伤性神经损伤管理新模式的认识。

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