Biological Sciences, University of Southampton, UK.
Faculty of Medicine and Centre for Hybrid Biodevices, Institute for Life Sciences, University of Southampton, UK.
J Neurosci Methods. 2019 May 1;319:69-76. doi: 10.1016/j.jneumeth.2018.09.032. Epub 2018 Sep 29.
Neurofibrillary tangles, formed of hyperphosphorylated, misfolded tau accumulations, are a pathological hallmark of neurodegenerative diseases such as Alzheimer's disease (AD) and frontotemporal dementia. The neuroanatomical localisation of tau pathology in AD brains of different disease stages suggests that tau tangle pathology is spreading throughout the brain along connected neuronal circuits. Pathogenic tau can act as a prion-like seed, inducing the misfolding of native tau and leading to disease propagation throughout the brain. However, it is not yet fully understood how tau spreads between individual neurons or brain regions. Here, we review the models for investigating tau propagation in vitro, and summarise the findings from key studies into the mechanisms of tau pathology propagation in disease.
神经原纤维缠结由过度磷酸化、错误折叠的tau 聚集形成，是阿尔茨海默病（AD）和额颞叶痴呆等神经退行性疾病的病理标志。在不同疾病阶段 AD 大脑中 tau 病理学的神经解剖定位表明，tau 缠结病理学沿着连接的神经元回路在整个大脑中传播。致病性 tau 可以像朊病毒样种子一样起作用，诱导天然 tau 的错误折叠，并导致疾病在整个大脑中传播。然而，tau 如何在单个神经元或脑区之间传播尚不完全清楚。在这里，我们回顾了体外研究 tau 传播的模型，并总结了关键研究中关于 tau 病理学在疾病中传播机制的发现。
