Ding Hui, Cui Xiang-Yu, Cui Su-Ying, Ye Hui, Hu Xiao, Zhao Hui-Ling, Liu Yu-Tong, Zhang Yong-He
Department of pharmacology, Peking University, School of Basic Medical Science, Beijing, 100191, China.
Department of pharmacology, Peking University, School of Basic Medical Science, Beijing, 100191, China.
Neurosci Lett. 2018 Nov 20;687:202-206. doi: 10.1016/j.neulet.2018.09.059. Epub 2018 Sep 29.
Hypothalamic-pituitary-adrenal (HPA) axis activity is commonly dysregulated in stress-related psychiatric disorders. The corticosterone rat model was developed to understand the influence of stress on depression-like symptomatology. To further understand the effects of corticosterone on the development of depression-like behavior, rats were continuously exposed to corticosterone (200 μg/ml) or vehicle via drinking water daily for 21 days. The rats underwent a series of behavioral tests, and electroencephalographical recordings were performed after 7, 14, and 21 days of treatment. The measurements included immobility time (i.e., despair) in the forced swim test, locomotor activity in the open field test, sucrose consumption (i.e., anhedonia) in the sucrose preference test, and sleep-wake parameters. The rats in the 7-day corticosterone exposure group exhibited depression-like behavior, including increases in despair, anhedonia, anxiety, and sleep impairments. The rats in the 14-day corticosterone exposure group exhibited normal patterns of behavior and sleep structure. When corticosterone exposure was extended to 21 days, depression-like symptoms recurred, including despair, anhedonia, anxiety, and sleep disturbances. Overall, the present study observed U-shaped depression-like effects across 3 weeks of corticosterone exposure via drinking water.
下丘脑-垂体-肾上腺（HPA）轴活动在应激相关精神障碍中通常失调。皮质酮大鼠模型的建立是为了了解应激对抑郁样症状的影响。为了进一步了解皮质酮对抑郁样行为发展的影响，大鼠通过每日饮用含皮质酮（200μg/ml）或赋形剂的水持续暴露21天。大鼠接受了一系列行为测试，并在治疗7天、14天和21天后进行脑电图记录。测量指标包括强迫游泳试验中的不动时间（即绝望程度）、旷场试验中的运动活动、蔗糖偏好试验中的蔗糖消耗（即快感缺失）以及睡眠-觉醒参数。7天皮质酮暴露组的大鼠表现出抑郁样行为，包括绝望、快感缺失、焦虑和睡眠障碍增加。14天皮质酮暴露组的大鼠表现出正常的行为模式和睡眠结构。当皮质酮暴露延长至21天时，抑郁样症状复发，包括绝望、快感缺失、焦虑和睡眠障碍。总体而言，本研究观察到通过饮水给予皮质酮3周会出现U型抑郁样效应。
