Chemotherapy for gestational trophoblastic tumors.
作者信息
Takamizawa H, Sekiya S, Kobayashi O, Matsui H
出版信息
Semin Surg Oncol. 1987;3(1):36-44. doi: 10.1002/ssu.2980030106.
PMID:3027827
Abstract
Virtually 100% of patients with nonmetastatic and low-risk metastatic trophoblastic tumors are now curable by only conventional chemotherapeutic agents such as methotrexate, actinomycin D, or their combination with or without other agents. However, approximately 30% of high-risk patients with metastatic trophoblastic tumors are resistant to conventional chemotherapy. All of the high-risk patients resistant to chemotherapy are those with metastatic choriocarcinoma. Thus, the efficacy of multidrug chemotherapy and combination chemotherapy of cisplatin or VP16-213 with other agents is now being examined.
摘要
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